Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder.
Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder.
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DOI：
10.3389/fpsyt.2021.659616
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发表时间：
2021
影响因子：
4.7
通讯作者：
Nakao T
中科院分区：
文献类型：
--
作者：
Murayama K;Tomiyama H;Tsuruta S;Ohono A;Kang M;Hasuzawa S;Mizobe T;Kato K;Togao O;Hiwatashi A;Nakao T
背景资料：虽然强迫症（OCD）患者存在静息状态下小脑-大脑功能连接异常的假说，但对其神经机制的研究较少。为了验证以前的研究结果，强迫症患者的大样本进行了研究，因为强迫症显示可能的异质性。方法：对47例未服药的强迫症患者和62例健康对照者进行静息态功能磁共振成像扫描。基于种子的连通性进行了检查，以调查强迫症患者与HC相比小脑-大脑功能连接的差异。分析功能连接与强迫症状严重程度的相关性。结果如下：在强迫症中，我们发现右小叶VI和左楔前叶之间的功能连接显著增加，这是默认模式网络（DMN）的一个组成部分，与HC相比。然而，右小叶VI-左楔前叶的连通性与强迫症的严重程度之间没有相关性。结论：这些发现表明，小脑和DMN之间的功能连接改变可能会导致与强迫症特征相关的内在大规模脑网络的变化。
Background: Although abnormality of cerebellar-cerebral functional connectivity at rest in obsessive-compulsive disorder (OCD) has been hypothesized, only a few studies have investigated the neural mechanism. To verify the findings of previous studies, a large sample of patients with OCD was studied because OCD shows possible heterogeneity. Methods: Forty-seven medication-free patients with OCD and 62 healthy controls (HCs) underwent resting-state functional magnetic imaging scans. Seed-based connectivity was examined to investigate differences in cerebellar-cerebral functional connectivity in OCD patients compared with HCs. Correlations between functional connectivity and the severity of obsessive-compulsive symptoms were analyzed. Results: In OCD, we found significantly increased functional connectivity between the right lobule VI and the left precuneus, which is a component of the default mode network (DMN), compared to HCs. However, there was no correlation between the connectivity of the right lobule VI-left precuneus and obsessive-compulsive severity. Conclusions: These findings suggest that altered functional connectivity between the cerebellum and DMN might cause changes in intrinsic large-scale brain networks related to the traits of OCD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
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