Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy.
Preparation and Application of Cell Membrane-Camouflaged Nanoparticles for Cancer Therapy.
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作者：
Zhai Y;Su J;Ran W;Zhang P;Yin Q;Zhang Z;Yu H;Li Y
癌症是全球主要的死亡原因之一。到目前为止，已经开发了许多治疗方法，尽管有效，但由于选择性低而具有严重的副作用。纳米颗粒可以通过特异性地将它们运送到肿瘤来提高其递送药物的治疗指数。然而，它们的外源性性质通常导致单核吞噬细胞系统的快速清除。最近，细胞膜包裹的纳米颗粒已经被研究用于癌症治疗，利用细胞膜的优异生物相容性和多功能性。在这篇综述中，我们总结了用于构建和表征仿生纳米颗粒的源材料和程序，重点是它们在癌症治疗中的应用。
Cancer is one of the leading causes of death worldwide. Many treatments have been developed so far, although effective, suffer from severe side effects due to low selectivity. Nanoparticles can improve the therapeutic index of their delivered drugs by specifically transporting them to tumors. However, their exogenous nature usually leads to fast clearance by mononuclear phagocytic system. Recently, cell membrane-camouflaged nanoparticles have been investigated for cancer therapy, taking advantages of excellent biocompatibility and versatile functionality of cell membranes. In this review, we summarized source materials and procedures that have been used for constructing and characterizing biomimetic nanoparticles with a focus on their application in cancer therapy.
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