Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
Prevalence, beliefs and impact of drug-drug interactions between antiretroviral therapy and illicit drugs among people living with HIV in Spain.
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DOI：
10.1371/journal.pone.0260334
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Fuster-RuizdeApodaca MJ
中科院分区：
文献类型：
--
作者：
Castro-Granell V;Garin N;Jaén Á;Cenoz S;Galindo MJ;Fuster-RuizdeApodaca MJ
吸毒意味着与艾滋病毒管理有关的重大挑战，特别是由于抗逆转录病毒疗法与非法药物之间潜在相互作用的风险增加。这项研究分析了艾滋病毒感染者（PLHIV）中pDDI的患病率和严重程度。它还探讨了他们对pDDI的认识和他们对可能引起的毒性的信念，以及pDDI对选定健康变量的影响。我们对33家西班牙医院和非政府组织进行了在线横断面调查，以收集人口统计数据和临床数据。根据利物浦大学开发的Interaction方法检查pDDI。本研究的样本由694名使用非法药物的艾滋病毒感染者组成。他们占参与调查的1 401名艾滋病毒感染者的49.5%。在排除了38名因缺乏ART或非法药物使用信息的参与者后，335名（51.1%）服用药物的参与者在ART和非法药物之间出现了一些潜在的显著pDDI，平均每位患者的pDDI为2.1±1.7（1-10）。最常参与pDDI的药物是可卡因、大麻、摇头丸和硝酸盐（“poppers”）。抗逆转录病毒治疗方案中pDDI的发生率为：蛋白酶抑制剂（41.7%）;整合酶增强方案（32.1%）和非核苷类逆转录酶抑制剂（26.3%）。对pDDI的认识及其潜在毒性的信念与故意不依从呈正相关（p<0.0001）。pDDI受试者的故意不依从率更高（2.19±1.04 vs. 1.93±0.94; p = 0.001）。pDDI的存在与分析的临床变量的较差结果无关。吸毒的艾滋病毒感染者中有很大一部分经历过药物依赖性疾病，因此需要密切监测。在HIV患者的临床管理中应考虑pDDI。充分了解艾滋病毒感染者使用药物时如何管理抗逆转录病毒疗法的pDDI和指标，可以改善抗逆转录病毒疗法的不依从性。
Drug use implies important challenges related to HIV management, particularly due to an increased risk of potential interactions between antiretroviral therapy (ART) and illicit drugs (pDDIs). This study analyses the prevalence and severity of pDDIs among people living with HIV (PLHIV). It also explores their awareness of pDDIs and their beliefs about the toxicity that they may cause, as well as the impact of pDDIs on selected health variables. We conducted an on-line cross-sectional survey across 33 Spanish hospitals and NGOs to collect demographics and clinical data. pDDIs were checked against the Interaction Checker developed by Liverpool University. The sample of the present study was composed of 694 PLHIV who used illicit drugs. They represented 49.5% of the 1,401 PLHIV that participated in the survey. After excluding 38 participants due to lack of information on their ART or illicit drug use, 335 (51.1%) participants consuming drugs presented with some potentially significant pDDIs between their ART and illicit drugs, with a mean of 2.1±1.7 (1–10) pDDIs per patient. The drugs most frequently involved in pDDIs were cocaine, cannabis, MDMA and nitrates ("poppers"). The prevalence of pDDIs across ART regimens was: protease inhibitors (41.7%); integrase inhibitor-boosted regimens (32.1%), and non-nucleoside reverse transcriptase inhibitors (26.3%). An awareness of pDDIs and beliefs about their potential toxicity correlated positively with intentional non-adherence (p<0.0001). Participants with pDDIs exhibited a higher prevalence of intentional non-adherence (2.19±1.04 vs. 1.93±0.94; p = 0.001). The presence of pDDIs was not associated with poorer results in the clinical variables analysed. A significant proportion of PLHIV who use drugs experience pDDIs, thereby requiring close monitoring. pDDIs should be considered in the clinical management of HIV patients. Adequate information about pDDIs and indicators about how to manage ART when PLHIV use drugs could improve ART non-adherence.
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抗逆转录病毒疗法与艾滋病毒系统滥用药物之间的药物相互作用。
影响因子：
4.3
作者：
Kumar S;Rao PS;Earla R;Kumar A
通讯作者：
Kumar A
DOI：
10.1016/j.jmii.2020.07.016
发表时间：
2021-10-15
影响因子：
7.4
作者：
Chen, Guan-Lin;Lin, Shang-Yi;Lu, Po-Liang
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Lu, Po-Liang
影响因子：
16.1
作者：
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通讯作者：
Lampe, Fiona C.
影响因子：
4.6
作者：
Grabovac I;Meilinger M;Schalk H;Leichsenring B;Dorner TE
通讯作者：
Dorner TE
影响因子：
5.2
作者：
Garin N;Velasco C;De Pourcq JT;Lopez B;Gutierrez Mdel M;Haro JM;Feliu A;Mangues MA;Trilla A
通讯作者：
Trilla A