Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis.
Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis.
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DOI：
10.1038/s41598-018-32478-z
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发表时间：
2018-09-19
影响因子：
4.6
通讯作者：
Suda T
中科院分区：
文献类型：
--
作者：
Suzuki Y;Yoshimura K;Enomoto Y;Yasui H;Hozumi H;Karayama M;Furuhashi K;Enomoto N;Fujisawa T;Nakamura Y;Inui N;Suda T
骨骼肌萎缩是肺部恶病质的主要成分，身体成分的变化与慢性阻塞性肺疾病和癌症的死亡率有关。然而，它与间质性肺疾病(ILDS)的相关性仍不清楚。我们假设身体成分的变化与ILDS的死亡率有关。我们测量了特发性肺纤维化(IPF；n = )和特发性胸膜实质纤维弹力增生症(IPPFE；n = 43)患者和对照组的竖脊肌横截面积(ESMCSA)和肌肉衰减(ESMMA)。随后，对预后的影响进行了评估。ILD患者的ESMCSA显著小于对照组，而ESMMA无显著差异。IPPFE患者与IPF患者相比，ESMCSA降低，BMI降低，而IPF患者ESMCSA降低，BMI没有下降。IPF患者ESMCSA越低，预后越差。相反，在IPPFE患者中，ESMMA降低与较差的生存相关。多因素分析显示IPF中的ESMCSA和IPPFE中的ESMMA是影响死亡的独立危险因素。在IPF和IPPFE患者中，身体成分的明显变化对预后有重要意义。低ESMCSA和ESMMA分别与IPF和IPPFE预后不良相关。这些结果提示，在处理IPF和IPPFE患者时，测量身体成分变化的价值。
Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associated with mortality in ILDs. We measured the cross-sectional-area (ESMCSA) and muscle attenuation (ESMMA) of erector-spinae muscles, as determined by CT-imaging, in patients with idiopathic pulmonary fibrosis (IPF; n = 131) and idiopathic pleuroparenchymal fibroelastosis (iPPFE; n = 43) and controls. Subsequently, implications with prognosis were evaluated. The ESMCSA of ILD patients, but not ESMMA, was significantly smaller than that in controls. Lower ESMCSA with decreased BMI were recorded in iPPFE patients versus IPF patients, whilst IPF patients had decreased ESMCSA without BMI decline. Lower ESMCSA in IPF patients were associated with poorer prognoses. Conversely, decreased ESMMA were associated with worse survival in iPPFE patients. Multivariate analyses showed that ESMCSA in IPF and ESMMA in iPPFE were independent risk factors for mortality. Distinct changes in body composition had prognostic significance among patients with IPF and iPPFE. Lower ESMCSA and ESMMA were independently associated with poor prognosis in IPF and iPPFE, respectively. These results suggest values to measure body composition changes in managing patients with IPF and iPPFE.
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DOI：
10.1183/09031936.00066414
发表时间：
2014-11
期刊：
The European respiratory journal
影响因子：
--
作者：
Maddocks M;Shrikrishna D;Vitoriano S;Natanek SA;Tanner RJ;Hart N;Kemp PR;Moxham J;Polkey MI;Hopkinson NS
通讯作者：
Hopkinson NS
影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1111/apha.12224
发表时间：
2014-03
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
Aubrey J;Esfandiari N;Baracos VE;Buteau FA;Frenette J;Putman CT;Mazurak VC
通讯作者：
Mazurak VC
影响因子：
8.9
作者：
Ebner, Nicole;Steinbeck, Lisa;Doehner, Wolfram;Anker, Stefan D.;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
24.3
作者：
Reddy, Taryn L.;Tominaga, Masaki;Nicholson, Andrew G.
通讯作者：
Nicholson, Andrew G.