Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.
Don't forget the little brain: A framework for incorporating the cerebellum into the understanding of cognitive aging.
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DOI：
10.1016/j.neubiorev.2022.104639
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发表时间：
2022-06
影响因子：
8.2
通讯作者：
Bernard, Jessica A.
中科院分区：
文献类型：
--
作者：
Bernard, Jessica A.
随着老年人口的迅速增长，考虑到对健康，独立性和生活质量的影响，提高对大脑和认知老化的理解至关重要。在这一点上，我们有一个发达的文献对大脑皮层的贡献认知在先进的年龄。然而，虽然这项工作是我们理解老年人大脑和行为的基础，但皮质下的贡献，特别是来自小脑的贡献，尚未被整合到这些模型和框架中。将小脑纳入认知老化模型是推动该领域向前发展的重要一步。最近也有人对阿尔茨海默氏症的这种结构感兴趣，这表明这种工作可能有助于我们对神经退行性疾病的理解。在这里，我提供了一个更新的概述小脑在先进的年龄，并提出它作为一个关键来源的脚手架或储备皮质功能。小脑功能受到的脑电相关影响会进一步影响皮层处理，可能导致许多在衰老中常见的激活模式。
With the rapidly growing population of older adults, an improved understanding of brain and cognitive aging is critical, given the impacts on health, independence, and quality of life. To this point, we have a well-developed literature on the cortical contributions to cognition in advanced age. However, while this work has been foundational for our understanding of brain and behavior in older adults, subcortical contributions, particularly those from the cerebellum, have not been integrated into these models and frameworks. Incorporating the cerebellum into models of cognitive aging is an important step for moving the field forward. There has also been recent interest in this structure in Alzheimer’s dementia, indicating that such work may be beneficial to our understanding of neurodegenerative disease. Here, I provide an updated overview of the cerebellum in advanced age and propose that it serves as a critical source of scaffolding or reserve for cortical function. Age-related impacts on cerebellar function further impact cortical processing, perhaps resulting in many of the activation patterns commonly seen in aging.
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