Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
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DOI：
10.3346/jkms.2015.30.5.586
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发表时间：
2015-05
影响因子：
4.5
通讯作者：
Kim IJ
中科院分区：
文献类型：
--
作者：
Kim WJ;Kim SS;Lee HC;Song SH;Bae MJ;Yi YS;Jeon YK;Kim BH;Kim YK;Kim IJ
本研究的目的是评价血浆成纤维细胞生长因子（FGF）-21与2型糖尿病患者冠状动脉病变（CAD）的关系。测定120例冠状动脉造影患者血清FGF-21水平。根据是否存在2型糖尿病和显著CAD将患者分为4组。动脉粥样硬化负荷通过两种血管造影评分获得：Gensini评分（GS）和程度评分（ES）。2型糖尿病患者FGF-21水平高于非糖尿病患者（P = 0.014）。单因素分析显示，所有患者的FGF-21水平与GS（r = 0.358，P < 0.001）和ES（r = 0.324，P < 0.001）显著相关。在调整了几个混杂因素后，所有患者中GS和ES均与FGF-21相关（分别为r = 0.271，P = 0.014; r = 0.217，P = 0.041）。然而，在最终模型中，FGF-21与GS和ES与2型糖尿病均失去显著相关性。2型糖尿病合并冠心病患者FGF-21水平升高。尽管在糖尿病患者中的作用有限，但FGF-21水平与CAD的血管造影严重程度和范围独立相关。
The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P < 0.001) and ES (r = 0.324, P < 0.001) in univariate analysis with all patients. After adjusting for several confounding factors, both GS and ES were associated with FGF-21 in all patients (r = 0.271, P = 0.014; r = 0.217, P = 0.041, respectively). However, FGF-21 lost significant correlation with both GS and ES with type 2 diabetes mellitus in the final model. The patients with type 2 diabetes mellitus and CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD.
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影响因子：
7.7
作者：
Hojman P;Pedersen M;Nielsen AR;Krogh-Madsen R;Yfanti C;Akerstrom T;Nielsen S;Pedersen BK
通讯作者：
Pedersen BK
影响因子：
3.7
作者：
Lin Z;Wu Z;Yin X;Liu Y;Yan X;Lin S;Xiao J;Wang X;Feng W;Li X
通讯作者：
Li X
影响因子：
4.8
作者：
SULLIVAN, DR;MARWICK, TH;FREEDMAN, SB
通讯作者：
FREEDMAN, SB
影响因子：
5.9
作者：
Seo JA;Kim NH
通讯作者：
Kim NH
影响因子：
5.1
作者：
An, So-Yeon;Lee, Min Suk;Lee, Kwan-Woo
通讯作者：
Lee, Kwan-Woo