Iterative Metaplasticity Across Timescales: How Circadian, Ultradian, and Infradian Rhythms Modulate Memory Mechanisms.

Iterative Metaplasticity Across Timescales: How Circadian, Ultradian, and Infradian Rhythms Modulate Memory Mechanisms.
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DOI:
10.1177/07487304211058256
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发表时间:
2022-03
影响因子:
3.5
通讯作者:
Spencer, Robert L.
Spencer, Robert L.
中科院分区:
生物学3区
文献类型:
--
作者:
Hartsock, Matthew J.;Strnad, Helen K.;Spencer, Robert L.

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近年来的工作为昼夜节律(每日),超昼夜(短于每日)和亚昼夜(长于每日)时间尺度的记忆功能和神经可塑性机制的调节提供了强有力的证据。尽管进展迅速,然而,该领域尚未采用一个通用的框架来描述生物节律在记忆中的总体作用。为此,他们引入了术语迭代超塑性,他们将其定义为“对在循环时基上重复的后续信号的接受性的门控”。核心概念是参与神经可塑性的分子的周期性调节可能产生神经可塑性能力的周期-即神经细胞经历活动依赖性变化的能力。尽管Iyer和同事专注于昼夜节律时间尺度,但我们认为他们的框架可能有助于了解生物节律如何更广泛地影响记忆。在这篇综述中,我们提供了一些例子和术语来解释迭代后可塑性的概念是如何在昼夜节律、超昼夜节律和亚昼夜节律的时间尺度上得到应用的。我们认为,迭代metaplasticity可能不仅支持的时间小生境的神经可塑性过程,但也在维持记忆功能的重要作用。
Work in recent years has provided strong evidence for the modulation of memory function and neuroplasticity mechanisms across circadian (daily), ultradian (shorter-than-daily), and infradian (longer-than-daily) timescales. In spite of rapid progress, however, the field has yet to adopt a general framework to describe the overarching role of biological rhythms in memory. To this end, introduced the term iterative metaplasticity, which they define as the “gating of receptivity to subsequent signals that repeats on a cyclic timebase.” The central concept is that the cyclic regulation of molecules involved in neuroplasticity may produce cycles in neuroplastic capacity – that is, the ability of neural cells to undergo activity-dependent change. Although Iyer and colleagues focus on the circadian timescale, we think their framework may be useful for understanding how biological rhythms influence memory more broadly. In this review, we provide examples and terminology to explain how the idea of iterative metaplasticity can be readily applied across circadian, ultradian, and infradian timescales. We suggest that iterative metaplasticity may not only support the temporal niching of neuroplasticity processes, but also serve an essential role in the maintenance of memory function.
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