Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insight into tissue mechanics.
Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insight into tissue mechanics.
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DOI：
10.3389/fncel.2014.00473
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发表时间：
2014
影响因子：
5.3
通讯作者：
Kawaguchi A
中科院分区：
文献类型：
--
作者：
Miyata T;Okamoto M;Shinoda T;Kawaguchi A
产生多种类型脑细胞的神经上皮（NE）或脑室区（VZ）是假复层的。在 NE/VZ 中，神经祖细胞沿顶端基底轴伸长，并且它们的细胞核呈现不同的顶端基底位置。这些细胞核以细胞周期依赖性方式移动，即在 G2 期向顶端移动，在 G1 期向基部移动，这一过程称为动间核迁移 (INM)。本综述将总结和讨论几个主题：神经祖细胞表现出的INM的性质、发育中的大脑皮层中与INM相关的机械困难、集体和有效INM背后的群落水平机制、当NE/VZ由于INM丧失而过度拥挤时对整体大脑形成的影响，以及神经祖细胞INM在哺乳动物物种之间是否以及如何变化。这些讨论将基于使用定量和机械方法从活体三维样本中获得的最新发现。在小鼠新皮质 NE/VZ 中诱导过度拥挤的实验以及小鼠和雪貂之间新皮质 INM 的比较表明，NE/VZ 细胞的行为可能受到细胞致密化的影响。考虑 NE/VZ 的物理方面以及与高度伪分层 (PS) 相关的机械困难对于更好地理解新皮质的发育和进化非常重要。
The neuroepithelium (NE) or ventricular zone (VZ), from which multiple types of brain cells arise, is pseudostratified. In the NE/VZ, neural progenitor cells are elongated along the apicobasal axis, and their nuclei assume different apicobasal positions. These nuclei move in a cell cycle–dependent manner, i.e., apicalward during G2 phase and basalward during G1 phase, a process called interkinetic nuclear migration (INM). This review will summarize and discuss several topics: the nature of the INM exhibited by neural progenitor cells, the mechanical difficulties associated with INM in the developing cerebral cortex, the community-level mechanisms underlying collective and efficient INM, the impact on overall brain formation when NE/VZ is overcrowded due to loss of INM, and whether and how neural progenitor INM varies among mammalian species. These discussions will be based on recent findings obtained in live, three-dimensional specimens using quantitative and mechanical approaches. Experiments in which overcrowding was induced in mouse neocortical NE/VZ, as well as comparisons of neocortical INM between mice and ferrets, have revealed that the behavior of NE/VZ cells can be affected by cellular densification. A consideration of the physical aspects in the NE/VZ and the mechanical difficulties associated with high-degree pseudostratification (PS) is important for achieving a better understanding of neocortical development and evolution.
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DOI：
10.1073/pnas.0308600100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Haubensak, W;Attardo, A;Huttner, WB
通讯作者：
Huttner, WB
影响因子：
25
作者：
Alexandre, Paula;Reugels, Alexander M.;Clarke, Jonathan D. W.
通讯作者：
Clarke, Jonathan D. W.
影响因子：
112.7
作者：
Iskratsch, Thomas;Wolfenson, Haguy;Sheetz, Michael P.
通讯作者：
Sheetz, Michael P.
影响因子：
5.3
作者：
Baye, Lisa M.;Link, Brian A.
通讯作者：
Link, Brian A.
影响因子：
16.2
作者：
Das, T;Payer, B;Harris, WA
通讯作者：
Harris, WA