Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1H and 31P Magnetic Resonance Spectroscopy
Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1H and 31P Magnetic Resonance Spectroscopy
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使用 1H 和 31P 磁共振波谱光刺激对人类视觉皮层乳酸和磷酸盐的影响
DOI：
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发表时间：
1992
影响因子：
6.3
通讯作者：
M. Weiner
中科院分区：
文献类型：
--
作者：
D. Sappey;G. Calabrese;G. Fein;J. Hugg;C. Biggins;M. Weiner
先前的动物和人类研究表明，光刺激（PS）增加脑血流量和葡萄糖摄取比氧消耗多得多，这表明选择性激活无氧糖酵解。本研究应用图像引导的~ 1H和~（31）P磁共振波谱（MRS）技术，对6名正常志愿者视皮层PS产生的乳酸和高能磷酸盐浓度进行了动态监测。PS最初在PS的前6.4分钟内产生视觉皮层乳酸的显著升高（至对照的250%，p < 0.01），随后随着PS继续而显著下降（p = 0.01）。在PS的前12.8分钟期间，PCr/Pi比从对照值显著降低（p < 0.05），并且pH略微升高。闪光后100 ~ 172 ms的视觉诱发电位P100正偏折在PS后12.8min较对照组显著降低（p < 0.05）。PS导致PCr/Pi降低的发现与以下观点一致：增加的脑活动刺激ATP酶，导致ADP升高，从而将肌酸激酶反应向ATP合成的方向转移。乳酸的上升与pH值的增加一起表明，细胞内的磷酸化，引起的肌酸激酶的移位，选择性地刺激糖酵解。
Previous animal and human studies showed that photic stimulation (PS) increased cerebral blood flow and glucose uptake much more than oxygen consumption, suggesting selective activation of anaerobic glycolysis. In the present studies, image-guided 1H and 31P magnetic resonance spectroscopy (MRS) was used to monitor the changes in lactate and high-energy phosphate concentrations produced by PS of visual cortex in six normal volunteers. PS initially produced a significant rise (to 250% of control, p < 0.01) in visual cortex lactate during the first 6.4 min of PS, followed by a significant decline (p = 0.01) as PS continued. The PCr/Pi ratios decreased significantly from control values during the first 12.8 min of PS (p < 0.05), and the pH was slightly increased. The positive P100 deflection of the visual evoked potential recorded between 100 and 172 ms after the strobe was significantly decreased from control at 12.8 min of PS (p < 0.05). The finding that PS caused decreased PCr/Pi is consistent with the view that increased brain activity stimulated ATPase, causing a rise in ADP that shifted the creatine kinase reaction in the direction of ATP synthesis. The rise in lactate together with an increase in pH suggest that intracellular alkalosis, caused by the shift of creatine kinase, selectively stimulated glycolysis.
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影响因子：
56.9
作者：
LYNCH, RM;PAUL, RJ
通讯作者：
PAUL, RJ
DOI：
10.1073/pnas.88.13.5829
发表时间：
1991-07-01
影响因子：
11.1
作者：
PRICHARD, J;ROTHMAN, D;SHULMAN, R
通讯作者：
SHULMAN, R
31P-NMR 研究正性肌力药物肾上腺素和哇巴因以及离子载体 R02-2985 (X537A) 在离体灌注大鼠心脏中的一些代谢和功能影响。
DOI：
10.1016/0167-4889(82)90008-8
发表时间：
1982
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Matthews,PM;Williams,SR;Seymour,AM;Schwartz,A;Dube,G;Gadian,DG;Radda,GK
通讯作者：
Radda,GK
体内脑代谢的核磁共振波谱。
影响因子：
13.9
作者：
Prichard,JW;Shulman,RG
通讯作者：
Shulman,RG
影响因子：
56.9
作者：
FOX, PT;RAICHLE, ME;DENCE, C
通讯作者：
DENCE, C