Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review.
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DOI：
10.1016/j.arr.2023.101962
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发表时间：
2023-07
影响因子：
13.1
通讯作者：
中科院分区：
文献类型：
--
作者：
脑血管病（CSVD）是血管性认知障碍的主要原因，与COVID-19有关。然而，在COVID-19患者中经常伴随CSVD病理的因素可能会影响脑血管并发症的发生率。因此，将COVID-19与CSVD联系起来的机制尚未被发现，并与年龄相关的合并症（如高血压）和急性感染期间的医疗干预相区分。我们旨在通过评估大脑、小脑和脑干的微出血和缺血性病变/梗死的定位，评估COVID-19急性和康复期患者的CSVD，并将COVID-19相关脑血管病理与上述因素区分开来。2022年12月，在PubMed、Web of Science和Embase上进行了系统搜索，使用预先建立的与成人CSVD病理相关的史或活动性COVID-19相关的搜索标准。从161项研究中，有59项符合入选标准。微出血和缺血性病变在COVID-19患者中对胼胝体和皮层下/深部白质有强烈的偏好，提示CSVD病理特征明显。这些发现对临床实践和生物医学研究具有重要意义，因为COVID-19可能独立地通过加剧年龄相关机制导致心血管疾病发病率增加。
Cerebral small vessel disease (CSVD) is the leading cause of vascular cognitive impairment and is associated with COVID-19. However, contributing factors that often accompany CSVD pathology in COVID-19 patients may influence the incidence of cerebrovascular complications. Thus, a mechanism linking COVID-19 and CSVD has yet to be uncovered and differentiated from age-related comorbidities (i.e., hypertension), and medical interventions during acute infection. We aimed to evaluate CSVD in acute and recovered COVID-19 patients and to differentiate COVID-19-related cerebrovascular pathology from the above-mentioned contributing factors by assessing the localization of microbleeds and ischemic lesions/infarctions in the cerebrum, cerebellum, and brainstem. A systematic search was performed in December 2022 on PubMed, Web of Science, and Embase using a pre-established search criterion related to history of, or active COVID-19 with CSVD pathology in adults. From a pool of 161 studies, 59 met eligibility criteria and were included. Microbleeds and ischemic lesions had a strong predilection for the corpus callosum and subcortical/deep white matter in COVID-19 patients, suggesting a distinct CSVD pathology. These findings have important implications for clinical practice and biomedical research as COVID-19 may independently, and through exacerbation of age-related mechanisms, contribute to increased incidence of CSVD.
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影响因子：
1.2
作者：
Finsterer, Josef
通讯作者：
Finsterer, Josef
DOI：
10.1186/s12941-020-00362-2
发表时间：
2020-05-15
影响因子：
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通讯作者：
Maes, Michael
影响因子：
3.6
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通讯作者：
Abid L