Per- and Polyfluoroalkyl Substances and Obesity, Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: A Review of Epidemiologic Findings.
Per- and Polyfluoroalkyl Substances and Obesity, Type 2 Diabetes and Non-alcoholic Fatty Liver Disease: A Review of Epidemiologic Findings.
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全氟烷基和多氟烷基物质与肥胖、2型糖尿病和非酒精性脂肪肝：流行病学调查结果综述。
DOI：
10.1080/02772248.2020.1763997
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发表时间：
2020
影响因子：
1.8
通讯作者：
Park Y
中科院分区：
文献类型：
--
作者：
Qi W;Clark JM;Timme-Laragy AR;Park Y
全氟和多氟烷基物质是一组在环境、野生动物和人类中广泛检测到的含氟表面活性剂，已被认为与有害健康影响有关。越来越多的文献讨论了它们对肥胖、糖尿病和非酒精性脂肪性肝病/非酒精性脂肪性肝炎的影响。本文综述了全氟烷基和多氟烷基物质的简要历史用途和化学成分、人类接触途径，以及暴露于全氟烷基和多氟烷基物质与肥胖、糖尿病和非酒精性脂肪性肝病/非酒精性脂肪性肝炎之间关系的流行病学证据。我们在PubMed上搜索人类研究，确定了22项关于肥胖的研究和32项关于糖尿病的研究，而只有1项关于非酒精性脂肪性肝病/非酒精性脂肪性肝炎的研究。大约2/3的研究报告说，全氟烷基物质和多氟烷基物质的暴露与肥胖和/或2型糖尿病的患病率呈正相关。然而，每种和多氟烷基物质与肥胖、糖尿病和非酒精性脂肪性肝病/非酒精性脂肪性肝炎之间的因果联系需要进一步的大规模前瞻性队列研究与机械性实验室研究相结合，以更好地评估这些联系。
Per- and polyfluoroalkyl substances, a group of fluoro-surfactants widely detected in the environment, wildlife and humans, have been linked to adverse health effects. A growing body of literature has addressed their effects on obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. This review summarizes the brief historical use and chemistry of per- and polyfluoroalkyl substances, routes of human exposure, as well as the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis. We identified 22 studies on obesity and 32 studies on diabetes, while only 1 study was found for non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis by searching PubMed for human studies. Approximately 2/3 of studies reported positive associations between per- and polyfluoroalkyl substances exposure and the prevalence of obesity and/or type 2 diabetes. Causal links between per- and polyfluoroalkyl substances and obesity, diabetes and non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis, however, require further large-scale prospective cohort studies combined with mechanistic laboratory studies to better assess these associations.
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Fernald 社区队列中纵向血清全氟烷基物质 (PFAS) 水平与甲状腺激素、肾功能和体重指数测量之间的关联。
DOI：
10.1016/j.envpol.2018.07.042
发表时间：
2018-11
期刊：
Environmental pollution (Barking, Essex : 1987)
影响因子：
--
作者：
Blake BE;Pinney SM;Hines EP;Fenton SE;Ferguson KK
通讯作者：
Ferguson KK
影响因子：
3.6
作者：
Wen-Ling Chen;Fang-Yu Bai;Ying-Chia Chang;Pau-Chung Chen;Chia-Yang Chen
通讯作者：
Chia-Yang Chen
影响因子：
11.8
作者：
Alderete, Tanya L.;Jin, Ran;Chatzi, Lida
通讯作者：
Chatzi, Lida
DOI：
10.1016/j.ijheh.2018.08.014
发表时间：
2019-01-01
影响因子：
6
作者：
Christensen, Krista Y.;Raymond, Michelle;Meiman, Jon
通讯作者：
Meiman, Jon
影响因子：
5
作者：
Andersen, Camilla Schou;Fei, Chunyuan;Olsen, Jorn
通讯作者：
Olsen, Jorn