Embryonic development of circadian clocks in the mammalian suprachiasmatic nuclei.
Embryonic development of circadian clocks in the mammalian suprachiasmatic nuclei.
复制标题
DOI：
10.3389/fnana.2014.00143
复制
发表时间：
2014
影响因子：
2.9
通讯作者：
Oster H
中科院分区：
文献类型：
--
作者：
Landgraf D;Koch CE;Oster H
在大多数物种中，自我维持的分子钟调节行为和生理的24小时节律。在哺乳动物中，位于下丘脑视交叉上核（SCN）中的昼夜节律起搏器接收来自视网膜的光信号，并在非SCN组织中接收从属时钟。发育过程中昼夜节律的出现已经被广泛研究多年。在小鼠中，胚胎下丘脑的假定SCN区域中的神经元发育发生在妊娠的第12-15天。SCN内回路在接下来的几天内分化，并且视网膜投射到达SCN，从而仅在出生后介导光夹带。相反，时钟基因机制的遗传成分表达得更早，在妊娠中期，SCN外植体和分离的神经元能够在培养中产生分子振荡。然而，在体内代谢的节奏在SCN，观察不早于19天的大鼠妊娠，和时钟基因的节奏表达是很难检测到，直到出生后。总之，这些数据表明，细胞耦合，因此，组织范围内的单细胞节律的同步化，可能只在胚胎发生过程中很晚才发展。在这篇迷你综述中，我们描述了SCN结构的发育起源，并总结了我们目前对胚胎发育过程中昼夜节律起搏器功能启动和夹带的了解。
In most species, self-sustained molecular clocks regulate 24-h rhythms of behavior and physiology. In mammals, a circadian pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN) receives photic signals from the retina and synchronizes subordinate clocks in non-SCN tissues. The emergence of circadian rhythmicity during development has been extensively studied for many years. In mice, neuronal development in the presumptive SCN region of the embryonic hypothalamus occurs on days 12–15 of gestation. Intra-SCN circuits differentiate during the following days and retinal projections reach the SCN, and thus mediate photic entrainment, only after birth. In contrast the genetic components of the clock gene machinery are expressed much earlier and during midgestation SCN explants and isolated neurons are capable of generating molecular oscillations in culture. In vivo metabolic rhythms in the SCN, however, are observed not earlier than the 19th day of rat gestation, and rhythmic expression of clock genes is hardly detectable until after birth. Together these data indicate that cellular coupling and, thus, tissue-wide synchronization of single-cell rhythms, may only develop very late during embryogenesis. In this mini-review we describe the developmental origin of the SCN structure and summarize our current knowledge about the functional initiation and entrainment of the circadian pacemaker during embryonic development.
登录
查看更多内容
DOI：
10.1155/np.1993.257
发表时间：
1993-10
期刊：
Journal of neural transplantation & plasticity
影响因子：
--
作者：
Kaufman CM;Menaker M
通讯作者：
Menaker M
影响因子：
3.5
作者：
Clark, Daniel D.;Gorman, Michael R.;Mellon, Pamela L.
通讯作者：
Mellon, Pamela L.
影响因子：
2.9
作者：
Kabrita, Colette S.;Davis, Fred C.
通讯作者：
Davis, Fred C.
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA