Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh.
Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh.
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DOI：
10.1289/ehp.9501
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发表时间：
2007-02
影响因子：
10.4
通讯作者：
Graziano JH
中科院分区：
文献类型：
--
作者：
Wasserman GA;Liu X;Parvez F;Ahsan H;Factor-Litvak P;Kline J;van Geen A;Slavkovich V;Loiacono NJ;Levy D;Cheng Z;Graziano JH
我们最近报道了一项对孟加拉国10岁儿童智力功能的横断面调查结果，这些儿童曾暴露于家中威尔斯的饮用水中的砷。我们提出了一个类似的调查结果301随机选择的6岁的孩子，他们的父母参加了我们正在进行的前瞻性研究的健康影响的Araihazar，孟加拉国的12,000名居民的As暴露。通过调查所有研究区域的威尔斯井，获得了每个家庭的水管威尔斯的水砷和锰浓度。首先在家中访问儿童和母亲，在那里测量家庭刺激的质量，然后在我们的实地诊所看到，儿童接受体检，其中评估体重，身高和头围。我们使用韦氏学前和小学智力量表第三版的子测试评估儿童的智力功能，通过对各个领域的加权项目进行求和，以创建言语、表现、处理速度和全量表原始分数。儿童提供尿液样本测量尿砷，并要求提供血液样本进行血铅测量。暴露于饮用水中的砷与调整水锰，血铅水平和已知有助于智力功能的社会人口学特征之前和之后的智力功能降低相关。与协变量调整，水作为仍然显着负相关的性能和处理速度的原始分数;协会不太强，比我们以前研究的10岁。这第二个横断面研究作为暴露扩大了我们的关注作为神经毒性的一个年轻的年龄组。
We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells. We present results of a similar investigation of 301 randomly selected 6-year-olds whose parents participated in our ongoing prospective study of the health effects of As exposure in 12,000 residents of Araihazar, Bangladesh. Water As and manganese concentrations of tube wells at each home were obtained by surveying all study region wells. Children and mothers were first visited at home, where the quality of home stimulation was measured, and then seen in our field clinic, where children received a medical examination wherein weight, height, and head circumference were assessed. We assessed children’s intellectual function using subtests drawn from the Wechsler Preschool and Primary Scale of Intelligence, version III, by summing weighted items across domains to create Verbal, Performance, Processing Speed, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and were asked to provide blood samples for blood lead measurements. Exposure to As from drinking water was associated with reduced intellectual function before and after adjusting for water Mn, for blood lead levels, and for sociodemographic features known to contribute to intellectual function. With covariate adjustment, water As remained significantly negatively associated with both Performance and Processing Speed raw scores; associations were less strong than in our previously studied 10-year-olds. This second cross-sectional study of As exposure expands our concerns about As neurotoxicity to a younger age group.
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影响因子：
10.4
作者：
Wasserman GA;Liu X;Parvez F;Ahsan H;Levy D;Factor-Litvak P;Kline J;van Geen A;Slavkovich V;LoIacono NJ;Cheng Z;Zheng Y;Graziano JH
通讯作者：
Graziano JH
影响因子：
8.3
作者：
Calderón, J;Navarro, ME;Díaz-Barriga, F
通讯作者：
Díaz-Barriga, F
影响因子：
3.5
作者：
MORTON, WE;CARON, GA
通讯作者：
CARON, GA
影响因子：
5
作者：
HEINEGAR.D;TIDERSTR.G
通讯作者：
TIDERSTR.G
影响因子：
2.6
作者：
Bartels, M;Rietveld, MJH;Boomsma, DI
通讯作者：
Boomsma, DI