Different modulation of common motor information in rat primary and secondary motor cortices.
Different modulation of common motor information in rat primary and secondary motor cortices.
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DOI：
10.1371/journal.pone.0098662
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Isomura Y
中科院分区：
文献类型：
--
作者：
Saiki A;Kimura R;Samura T;Fujiwara-Tsukamoto Y;Sakai Y;Isomura Y
啮齿类动物具有初级和次级运动皮层，它们通过直接和平行投射到脊髓来参与自主运动的执行。然而，目前还不清楚啮齿动物的次级运动皮层是否有任何不同于初级运动皮层的运动功能，以适当地控制随意运动。在本研究中，我们定量研究了神经元活动的尾侧前肢区（CFA）的初级运动皮层和喙侧前肢区（RFA）的次级运动皮层在头部固定大鼠进行前肢运动（推，握，拉杠杆）。我们发现CFA和RFA神经元之间几乎没有重大差异，无论神经元亚型，不仅在其基础尖峰特性，而且在时间过程中，幅度和方向偏好的功能激活简单的前肢运动。然而，与CFA神经元相比，RFA神经元的功能激活明显更容易受到行为情境的改变，导致奖励的“奖励”反应或奖励水之后的“完成”反应，这可能伴随着一些内部适应而不影响运动输出。我们的研究结果表明，虽然CFA和RFA神经元通常处理基本的运动信息，以适当地控制前肢运动，RFA神经元可能在功能上分化，以整合运动信息与内部状态信息，以适应目标导向的行为。
Rodents have primary and secondary motor cortices that are involved in the execution of voluntary movements via their direct and parallel projections to the spinal cord. However, it is unclear whether the rodent secondary motor cortex has any motor function distinct from the primary motor cortex to properly control voluntary movements. In the present study, we quantitatively examined neuronal activity in the caudal forelimb area (CFA) of the primary motor cortex and rostral forelimb area (RFA) of the secondary motor cortex in head-fixed rats performing forelimb movements (pushing, holding, and pulling a lever). We found virtually no major differences between CFA and RFA neurons, regardless of neuron subtypes, not only in their basal spiking properties but also in the time-course, amplitude, and direction preference of their functional activation for simple forelimb movements. However, the RFA neurons, as compared with the CFA neurons, showed obviously a greater susceptibility of their functional activation to an alteration in a behavioral situation, a 'rewarding' response that leads to reward or a 'consummatory' response that follows reward water, which might be accompanied by some internal adaptations without affecting the motor outputs. Our results suggest that, although the CFA and RFA neurons commonly process fundamental motor information to properly control forelimb movements, the RFA neurons may be functionally differentiated to integrate motor information with internal state information for an adaptation to goal-directed behaviors.
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影响因子：
25
作者：
Anderson, Charles T.;Sheets, Patrick L.;Kiritani, Taro;Shepherd, Gordon M. G.
通讯作者：
Shepherd, Gordon M. G.
影响因子：
3.5
作者：
Hira R;Ohkubo F;Tanaka YR;Masamizu Y;Augustine GJ;Kasai H;Matsuzaki M
通讯作者：
Matsuzaki M
影响因子：
5.3
作者：
Bonazzi, Laura;Viaro, Riccardo;Franchi, Gianfranco
通讯作者：
Franchi, Gianfranco
影响因子：
2.7
作者：
Hyland, B
通讯作者：
Hyland, B
DOI：
10.1073/pnas.1316885110
发表时间：
2013-12-24
影响因子：
11.1
作者：
Guggenmos, David J.;Azin, Meysam;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.