Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life.
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life.
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DOI：
10.1002/hbm.20868
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发表时间：
2010-03
影响因子：
4.8
通讯作者：
Franceschini, Maria Angela
中科院分区：
文献类型：
--
作者：
Roche-Labarbe, Nadege;Carp, Stefan A.;Surova, Andrea;Patel, Megha;Boas, David A.;Grant, R. Ellen;Franceschini, Maria Angela
关键词：
由于围产期脑损伤的原因仍不清楚，并且血流动力学不稳定在其病因中可能发挥的作用，因此需要对新生儿脑血流动力学进行床边监测，并以年龄函数的标准值进行监测。在本研究中，我们将脑组织氧合 (StO2) 和脑血容量 (CBV) 的定量频域近红外光谱 (FD-NIRS) 测量与脑血流指数 (CBFix) 的扩散相关光谱 (DCS) 测量相结合，以测试早产儿 CBV-CBF 关系的有效性，并在有或没有 CBFix 测量的情况下估计脑氧代谢率 (rCMRO2)。我们对 11 名没有已知神经系统问题的早产新生儿（胎龄 28-34 周）进行了测量，从 1 周到 6 周龄，每周测量一次。通过经颅多普勒 (TCD) 采集 9 名患者大脑中动脉的脑血流速度，并与 DCS 值进行比较。结果显示，在生命的前六周内，StO2 稳步下降，而 CBV 保持稳定，而 CBFix 则稳定增加。根据 FD-NIRS 估计的 rCMRO2 保持不变，但显示出广泛的个体差异。根据 FD-NIRS 和 DCS 计算得出的 rCMRO2 在生命的前六周内增加了 40%，并且个体间变异性降低。 TCD 和 DCS 值呈正相关。总之，FD-NIRS联合DCS提供了一种安全、定量的床边方法来评估早产儿大脑的CBV、StO2、CBF和rCMRO2，有利于患者的个体化随访和比较。稳定的 CBV-CBF 关系对于早产儿可能无效。
With the causes of perinatal brain injuries still unclear and the probable role of hemodynamic instability in their etiology, bedside monitoring of neonatal cerebral hemodynamics with standard values as a function of age are needed. In this study, we combined quantitative frequency domain near infrared spectroscopy (FD-NIRS) measures of cerebral tissue oxygenation (StO2) and cerebral blood volume (CBV) with diffusion correlation spectroscopy (DCS) measures of a cerebral blood flow index (CBFix) to test the validity of the CBV-CBF relationship in premature neonates and to estimate cerebral metabolic rate of oxygen (rCMRO2) with or without the CBFix measurement. We measured 11 premature neonates (28–34 weeks gestational age) without known neurological issues, once a week from one to six weeks of age. In nine patients, cerebral blood velocities from the middle cerebral artery were collected by transcranial Doppler (TCD) and compared with DCS values. Results show a steady decrease in StO2 during the first six weeks of life while CBV remains stable, and a steady increase in CBFix. rCMRO2 estimated from FD-NIRS remains constant but shows wide interindividual variability. rCMRO2 calculated from FD-NIRS and DCS combined increased by 40% during the first six weeks of life with reduced interindividual variability. TCD and DCS values are positively correlated. In conclusion, FD-NIRS combined with DCS offers a safe and quantitative bedside method to assess CBV, StO2, CBF, and rCMRO2 in the premature brain, facilitating individual follow-up and comparison among patients. A stable CBV-CBF relationship may not be valid for premature neonates.
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影响因子：
5.2
作者：
BODE, H;WAIS, U
通讯作者：
WAIS, U
影响因子：
3.8
作者：
Carlsson, Jakob;Lagercrantz, Hugo;Bartocci, Marco
通讯作者：
Bartocci, Marco
影响因子：
56.9
作者：
CHUGANI, HT;PHELPS, ME
通讯作者：
PHELPS, ME
影响因子：
3.6
作者：
Franceschini, Maria Angela;Thaker, Sonal;Grant, P. Ellen
通讯作者：
Grant, P. Ellen
DOI：
10.1097/00004647-200405000-00005
发表时间：
2004-05-01
影响因子：
6.3
作者：
Durduran, T;Burnett, MG;Greenberg, JH
通讯作者：
Greenberg, JH