The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding.
The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding.
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DOI：
10.1038/s41390-021-01831-w
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发表时间：
2022-09
影响因子：
3.6
通讯作者：
Lal, Charitharth, V
中科院分区：
文献类型：
--
作者：
Salas, Ariel A.;Willis, Kent A.;Carlo, Waldemar A.;Yi, Nengjun;Zhang, Li;Van der Pol, William J.;Younge, Noelle E.;Lefkowitz, Elliot J.;Lal, Charitharth, V
早期饲喂会影响肠道微生物群的发育。我们收集了极早产儿的粪便样本，随机分为提前（喂养第2天）和延迟（喂养第5天）两组。研究完成后，我们比较了在三个不同时间点（第1周、第2周和第3周）获得的样本，使用未调整和调整的负二项和零膨胀混合模型来确定研究组之间特定分类群的纵向差异。根据分娩方式、母乳摄入量和抗生素暴露对分析进行了调整。我们分析了来自51名婴儿的137份粪便样本。在未调整和调整后的分析中，我们没有观察到早期喂养组早期向更高的样品内微生物多样性（即α多样性）过渡，也没有观察到早期喂养组样品之间微生物多样性（即β多样性）的显著差异。我们的纵向单分类群分析发现，乳球菌属、微球菌属和嗜杆菌属在组间存在一致的差异。独立于分娩方式、抗生素暴露和母乳喂养的单分类群分析的差异表明，肠内喂养量的早期进展可能有益。然而，这种饮食干预似乎并没有增加出生后28天肠道微生物群的多样性。ClinicalTrials.gov识别码：NCT02915549。肠内喂养量的早期进展减少了极早产儿肠外营养的持续时间和中心静脉通路的需要。肠内喂养的早期进展导致肠道微生物组纵向分析中的单分类群差异，但在出生后的前28天内，它似乎并没有增加肠道微生物组的多样性。肠内喂养试验的随机化为评估母乳饮食对肠道微生物组的影响创造了有吸引力的机会。
Early progression of feeding could influence the development of the gut microbiome. We collected fecal samples from extremely preterm infants randomized to receive either early (feeding day 2) or delayed (feeding day 5) feeding progression. After study completion, we compared samples obtained at three different time points (week 1, week 2, and week 3) to determine longitudinal differences in specific taxa between the study groups using unadjusted and adjusted negative binomial and zero-inflated mixed models. Analyses were adjusted for a mode of delivery, breastmilk intake, and exposure to antibiotics. We analyzed 137 fecal samples from 51 infants. In unadjusted and adjusted analyses, we did not observe an early transition to higher microbial diversity within samples (i.e., alpha diversity) or significant differences in microbial diversity between samples (i.e., beta diversity) in the early feeding group. Our longitudinal, single-taxon analysis found consistent differences in the genera Lactococcus, Veillonella, and Bilophila between groups. Differences in single-taxon analyses independent of the mode of delivery, exposure to antibiotics, and breastmilk feeding suggest potential benefits of early progression of enteral feeding volumes. However, this dietary intervention does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. ClinicalTrials.gov identifier: NCT02915549. Early progression of enteral feeding volumes with human milk reduces the duration of parenteral nutrition and the need for central venous access among extremely preterm infants. Early progression of enteral feeding leads to single-taxon differences in longitudinal analyses of the gut microbiome, but it does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. Randomization in enteral feeding trials creates appealing opportunities to evaluate the effects of human milk diets on the gut microbiome.
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DOI：
10.1093/bioinformatics/btw725
发表时间：
2017-03-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Zakrzewski M;Proietti C;Ellis JJ;Hasan S;Brion MJ;Berger B;Krause L
通讯作者：
Krause L
影响因子：
5.7
作者：
Knapp S;Brodal C;Peterson J;Qi F;Kreth J;Merritt J
通讯作者：
Merritt J
影响因子：
4.6
作者：
Sato-Suzuki Y;Washio J;Wicaksono DP;Sato T;Fukumoto S;Takahashi N
通讯作者：
Takahashi N
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
3.7
作者：
Mashima I;Theodorea CF;Thaweboon B;Thaweboon S;Nakazawa F
通讯作者：
Nakazawa F