Antioxidant and Antimutagenic Activities of Different Fractions from the Leaves of Rhododendron arboreum Sm. and Their GC-MS Profiling.
Antioxidant and Antimutagenic Activities of Different Fractions from the Leaves of Rhododendron arboreum Sm. and Their GC-MS Profiling.
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DOI：
10.3390/molecules23092239
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发表时间：
2018-09-03
期刊：
影响因子：
--
通讯作者：
Ahmad P
中科院分区：
文献类型：
--
作者：
Gautam V;Kohli SK;Arora S;Bhardwaj R;Kazi M;Ahmad A;Raish M;Ganaie MA;Ahmad P
在这个城市化和环境污染的时代，来自植物的抗氧化剂和抗突变剂是人类健康的保障。本研究分析了亚洲杜鹃正己烷、氯仿和乙酸乙酯提取物的抗氧化和抗突变作用。叶，并确定其化学成分。不同组分抑制脂质过氧化，抑制一氧化氮自由基的产生，并防止脱氧核糖降解。在鼠伤寒沙门氏菌的两种测试菌株（TA-98和TA-100）中，分析叶级分对4-硝基-O-苯二胺、叠氮化钠和2-氨基芴诱变剂的抗诱变活性。使用预孵育和共孵育模式进行实验。预孵育方式对间接致突变剂的诱变效果最好。通过GC-MS分析，在不同级分中确认了许多生物活性成分的存在。研究表明，红曲霉具有较强的抗氧化和抗突变活性。树木园的叶子。我们认为R.植物园的可能对应的GC-MS分析所确定的植物化学物质的组合效应。据我们所知，这是第一次报道的抗突变活性的R。树木园的叶子。
In this era of urbanization and environmental pollution, antioxidants and antimutagens derived from plants are promising safeguards for human health. In the current investigation, we analyzed the antioxidant and antimutagenic effects of the hexane, chloroform, and ethyl acetate fractions of Rhododendron arboreum Sm. leaves and determined their chemical composition. The different fractions inhibited lipid peroxidation, repressed the production of nitric oxide radicals, and prevented deoxyribose degradation. The antimutagenic activity of the leaf fractions was analyzed against 4-nitro-O-phenylenediamine, sodium azide and 2-aminofluorene mutagens in two test strains (TA-98 and TA-100) of Salmonella typhimurium. The experiment was conducted using pre- and co-incubation modes. The best results were obtained in the pre-incubation mode, and against indirect acting mutagen. The presence of a number of bioactive constituents was confirmed in the different fractions by GC-MS analysis. The study reveals the strong antioxidant and antimutagenic activity of R. arboreum leaves. We propose that those activities of R. arboreum might correspond to the combined effect of the phytochemicals identified by GC-MS analysis. To the best of our knowledge, this is the first report on the antimutagenic activity of R. arboreum leaves.
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影响因子：
8.8
作者：
Negi, PS;Jayaprakasha, GK;Jena, BS
通讯作者：
Jena, BS
影响因子：
2.1
作者：
Ajith, T. A.;Ann, Marry;Thomas, Joe
通讯作者：
Thomas, Joe
DOI：
10.1006/bbrc.1994.1764
发表时间：
1994-06-15
影响因子：
3.1
作者：
MARCOCCI, L;MAGUIRE, JJ;PACKER, L
通讯作者：
PACKER, L
影响因子：
4.4
作者：
Hornby, JM;Jensen, EC;Nickerson, KW
通讯作者：
Nickerson, KW
影响因子：
3.9
作者：
ARUOMA, OI;GROOTVELD, M;HALLIWELL, B
通讯作者：
HALLIWELL, B