Cortical grey matter volume and sensorimotor gating in schizophrenia.
Cortical grey matter volume and sensorimotor gating in schizophrenia.
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DOI：
10.1016/j.cortex.2007.11.007
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发表时间：
2008-10
期刊：
影响因子：
3.6
通讯作者：
Kuipers, Elizabeth
中科院分区：
文献类型：
--
作者：
Kumari, Veena;Fannon, Dominic;Geyer, Mark A.;Premkumar, Preethi;Antonova, Elena;Simmons, Andrew;Kuipers, Elizabeth
惊吓反应的预脉冲抑制(PPI)是一种跨物种的感觉运动门控测量方法，它为研究很大一部分精神分裂症患者无法有效筛选无关感觉输入的已知能力提供了有价值的工具。在实验动物中，皮质-纹状体-苍白球-丘脑回路被认为对PPI的调制负责。在许多神经精神障碍中观察到PPI缺陷，其特征是该回路在某种程度上异常，以及最近在健康参与者中进行的功能神经成像研究的结果，支持了这一回路参与人类PPI的研究。目前的研究试图在42名稳定的男性精神分裂症门诊患者中调查PPI的结构神经相关性。参与者接受了1.5T的磁共振成像(MRI)，并使用右眼下方眼轮匝肌的肌电记录对声学PPI进行了(离线)评估。使用SPM2中实现的基于优化体积体素的形态计量学来研究PPI(脉冲起始至脉冲起始间隔120毫秒)与区域灰质(GM)体积的关系。前额叶背外侧、额中、眶/内侧前额叶皮质的PPI与GM体积呈显著正相关。我们的发现与(A)先前关于PPI对大脑皮质以“自上而下”方式控制的认知过程易感性的假设是一致的，(B)假设额叶皮质的神经资源受损有助于精神分裂症患者PPI的降低。
Prepulse inhibition (PPI) of the startle response, a cross-species measure of sensorimotor gating, provides a valuable tool to study the known inability of a large proportion of individuals with schizophrenia to effectively screen out irrelevant sensory input. The cortico-striato-pallido-thalamic circuitry is thought to be responsible for modulation of PPI in experimental animals. The involvement of this circuitry in human PPI is supported by observations of deficient PPI in a number of neuropsychiatric disorders that are characterised by abnormalities at some level in this circuitry, and findings of recent functional neuroimaging studies in healthy participants. The current study sought to investigate the structural neural correlates of PPI in a sample of 42 stable male outpatients with schizophrenia. Participants underwent magnetic resonance imaging (MRI) at 1.5 T and were assessed (off-line) on acoustic PPI using electromyographic recordings of the orbicularis oculi muscle beneath the right eye. Optimised volumetric voxel-based morphometry implemented in SPM2 was used to investigate the relationship of PPI (prepulse onset-to-pulse onset interval 120 msec) to regional grey matter (GM) volumes. Significant positive correlations were obtained between PPI and GM volume in the dorsolateral prefrontal, middle frontal and the orbital/medial prefrontal cortices. Our findings are consistent with (a) previous suggestions of susceptibility of PPI to cognitive processes controlled in a ‘top down’ manner by the cortex and (b) the hypothesis that compromised neural resources in the frontal cortex contribute to reduced PPI in schizophrenia.
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