Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination.
Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination.
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八胺能神经元在果蝇幼虫蘑菇体花冠中有多个靶点，可调节行为气味辨别。
DOI：
10.1101/lm.052159.120
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Masuda-Nakagawa LM
中科院分区：
文献类型：
--
作者：
Wong JYH;Wan BA;Bland T;Montagnese M;McLachlan AD;O'Kane CJ;Zhang SW;Masuda-Nakagawa LM
对感觉信号的辨别对于有机体在给定的行为背景下形成和检索相关记忆是必不可少的。通过哺乳动物的去甲肾上腺素能输入或昆虫的章鱼胺（OA）所携带的信号，通过行为状态的变化动态地修改感觉表征，促进行为的情境依赖性选择。为了了解这种信号的电路机制，我们的特点是功能的两个OA神经元，sVUM 1神经元，起源于食管下区（SEZ）和目标的输入区域的记忆中心，蘑菇体（MB）花萼，在幼虫果蝇。我们发现sVUM 1神经元靶向多个神经元，包括嗅觉投射神经元（PN），抑制神经元APL，和一对外在输出神经元，但相对较少的蘑菇体内在神经元，Kenyon细胞。PN终末携带OA受体Oamb，一种果蝇α1-肾上腺素能受体直系同源物。使用气味辨别学习范例，我们表明OA神经元的光遗传学激活损害了对相似气味的辨别，但不损害学习能力。我们的研究结果表明，sVUM 1神经元修改气味表征通过多个外在的输入在感觉输入区MB嗅觉学习电路。
Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval Drosophila. We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a Drosophila α1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit.
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DOI：
10.1098/rstb.2017.0380
发表时间：
2018-09-10
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Cantarelli M;Marin B;Quintana A;Earnshaw M;Court R;Gleeson P;Dura-Bernal S;Silver RA;Idili G
通讯作者：
Idili G
影响因子：
2.5
作者：
Busch, Sebastian;Selcho, Mareike;Tanimoto, Hiromu
通讯作者：
Tanimoto, Hiromu
影响因子：
2.5
作者：
Aoki, Kozue;Kosakai, Kumiko;Yoshino, Masami
通讯作者：
Yoshino, Masami
影响因子：
3.8
作者：
COBB, M;DANNET, F
通讯作者：
DANNET, F
影响因子：
4.5
作者：
Aso Y;Herb A;Ogueta M;Siwanowicz I;Templier T;Friedrich AB;Ito K;Scholz H;Tanimoto H
通讯作者：
Tanimoto H