SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021: a cross-sectional, nationally representative, age-stratified serosurvey.
SARS-CoV-2 antibody prevalence in Sierra Leone, March 2021: a cross-sectional, nationally representative, age-stratified serosurvey.
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塞拉利昂的SARS-COV-2抗体患病率，2021年3月：横断面，全国代表性，年龄分层的血清疗法。
DOI：
10.1136/bmjgh-2021-007271
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发表时间：
2021-11
影响因子：
8.1
通讯作者：
Richardson ET
中科院分区：
文献类型：
--
作者：
Barrie MB;Lakoh S;Kelly JD;Kanu JS;Squire JS;Koroma Z;Bah S;Sankoh O;Brima A;Ansumana R;Goldberg SA;Chitre S;Osuagwu C;Frankfurter R;Maeda J;Barekye B;Numbere TW;Abdulaziz M;Mounts A;Blanton C;Singh T;Samai M;Vandi M;Richardson ET
截至2021年3月26日，非洲疾病控制和预防中心在55个非洲联盟成员国中报告了4 159 055例COVID-19病例和111 357例死亡;然而，截至2021年10月，尚无国家公布具有全国代表性的血清调查。这些数据对于了解该流行病在非洲大陆的进展、评估遏制措施和政策规划至关重要。我们于2021年3月在塞拉利昂进行了一项具有全国代表性的跨部门、年龄分层血清调查，在全国随机选择了120个普查区，并在每个普查区随机选择了10个家庭。每个选定家庭有一至两人接受访谈，以收集有关社会人口统计资料、提示COVID-19的症状、实验室确诊COVID-19病例的暴露史以及COVID-19病史的信息。通过指尖采血采集毛细血管血，并使用Hangzhou Biotest Biotech RightSign COVID-19 IgG/IgM Rapid Test Cassette检测血液样本。在应用采样权重后估计总血清阳性率。总体加权血清阳性率为2.6%（95% CI 1.9%-3.4%）。这是报告病例数的43倍。农村血清阳性率为1.8%（95%CI 1.0%至2.5%），城市血清阳性率为4.2%（95%CI 2.6%至5.7%）。与欧洲和美洲国家相比，总体血清阳性反应率较低（表明塞拉利昂的遏制措施相对成功）。这对该国的第三波（始于2021年6月）产生了影响，在此期间，截至本月底，平均每日报告病例数为87例：这可能是每天3700例实际感染，要求在一个只有0.2%的人完全接种疫苗的国家采取更强有力的遏制措施。这也可能反映出整个非洲大陆的发病率和死亡率严重低报。
As of 26 March 2021, the Africa Centres for Disease Control and Prevention had reported 4 159 055 cases of COVID-19 and 111 357 deaths among the 55 African Union member states; however, no country has published a nationally representative serosurvey as of October 2021. Such data are vital for understanding the pandemic’s progression on the continent, evaluating containment measures, and policy planning. We conducted a cross-sectional, nationally representative, age-stratified serosurvey in Sierra Leone in March 2021 by randomly selecting 120 Enumeration Areas throughout the country and 10 randomly selected households in each of these. One to two persons per selected household were interviewed to collect information on sociodemographics, symptoms suggestive of COVID-19, exposure history to laboratory-confirmed COVID-19 cases, and history of COVID-19 illness. Capillary blood was collected by fingerstick, and blood samples were tested using the Hangzhou Biotest Biotech RightSign COVID-19 IgG/IgM Rapid Test Cassette. Total seroprevalence was estimated after applying sampling weights. The overall weighted seroprevalence was 2.6% (95% CI 1.9% to 3.4%). This was 43 times higher than the reported number of cases. Rural seropositivity was 1.8% (95% CI 1.0% to 2.5%), and urban seropositivity was 4.2% (95% CI 2.6% to 5.7%). Overall seroprevalence was low compared with countries in Europe and the Americas (suggesting relatively successful containment in Sierra Leone). This has ramifications for the country’s third wave (which started in June 2021), during which the average number of daily reported cases was 87 by the end of the month:this could potentially be on the order of 3700 actual infections per day, calling for stronger containment measures in a country with only 0.2% of people fully vaccinated. It may also reflect significant under-reporting of incidence and mortality across the continent.
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影响因子：
13.6
作者：
Peluso MJ;Takahashi S;Hakim J;Kelly JD;Torres L;Iyer NS;Turcios K;Janson O;Munter SE;Thanh C;Donatelli J;Nixon CC;Hoh R;Tai V;Fehrman EA;Hernandez Y;Spinelli MA;Gandhi M;Palafox MA;Vallari A;Rodgers MA;Prostko J;Hackett J Jr;Trinh L;Wrin T;Petropoulos CJ;Chiu CY;Norris PJ;DiGermanio C;Stone M;Busch MP;Elledge SK;Zhou XX;Wells JA;Shu A;Kurtz TW;Pak JE;Wu W;Burbelo PD;Cohen JI;Rutishauser RL;Martin JN;Deeks SG;Henrich TJ;Rodriguez-Barraquer I;Greenhouse B
通讯作者：
Greenhouse B
影响因子：
3.8
作者：
Richardson ET;Kelly JD;Barrie MB;Mesman AW;Karku S;Quiwa K;Marsh RH;Koedoyoma S;Daboh F;Barron KP;Grady M;Tucker E;Dierberg KL;Rutherford GW;Barry M;Jones JH;Murray MB;Farmer PE
通讯作者：
Farmer PE
影响因子：
6.4
作者：
Kelly, J. Daniel;Barrie, Mohamed Bailor;Richardson, Eugene T.
通讯作者：
Richardson, Eugene T.
影响因子：
105.7
作者：
Mwananyanda, Lawrence;Gill, Christopher J.;Thea, Donald
通讯作者：
Thea, Donald
DOI：
10.1016/s0140-6736(21)00632-2
发表时间：
2021-04-03
期刊：
Lancet (London, England)
影响因子：
--
作者：
Salyer SJ;Maeda J;Sembuche S;Kebede Y;Tshangela A;Moussif M;Ihekweazu C;Mayet N;Abate E;Ouma AO;Nkengasong J
通讯作者：
Nkengasong J