Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus.
Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus.
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DOI：
10.1016/j.cbpc.2017.10.008
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Fry BG
中科院分区：
文献类型：
--
作者：
Dobson J;Yang DC;Op den Brouw B;Cochran C;Huynh T;Kurrupu S;Sánchez EE;Massey DJ;Baumann K;Jackson TNW;Nouwens A;Josh P;Neri-Castro E;Alagón A;Hodgson WC;Fry BG
虽然一些美国种群的莫哈维响尾蛇（Crotalus scutulatus scutulatus）因具有强烈的神经毒性而臭名昭著，但墨西哥亚种C。S. salvini（Huamantlan响尾蛇）在很大程度上除了对小鼠进行粗略的致死性测试之外还没有进行过研究。在这项研究中，我们表明，至少有一些种群的这种蛇是强大的神经毒性，因为它的北方表亲。对墨西哥抗蛇毒血清Antivipmyn的测试表明，完全没有中和C。S. salvini毒液，而美国亚种C. S. scutulatus被延迟但最终没有被消除。这些结果记录了墨西哥蛇未被认识到的强效神经作用，并强调了该亚种的医学重要性，这一发现因抗蛇毒血清的无效而得到加强。这些结果也影响了我们对响尾蛇毒液进化的理解，这表明神经毒性是该物种的祖先特征，而美国种群缺乏神经毒性。
While some US populations of the Mohave rattlesnake (Crotalus scutulatus scutulatus) are infamous for being potently neurotoxic, the Mexican subspecies C. s. salvini (Huamantlan rattlesnake) has been largely unstudied beyond crude lethality testing upon mice. In this study we show that at least some populations of this snake are as potently neurotoxic as its northern cousin. Testing of the Mexican antivenom Antivipmyn showed a complete lack of neutralisation for the neurotoxic effects of C. s. salvini venom, while the neurotoxic effects of the US subspecies C. s. scutulatus were time-delayed but ultimately not eliminated. These results document unrecognised potent neurological effects of a Mexican snake and highlight the medical importance of this subspecies, a finding augmented by the ineffectiveness of the Antivipmyn antivenom. These results also influence our understanding of the venom evolution of Crotalus scutulatus, suggesting that neurotoxicity is the ancestral feature of this species, with the US populations which lack neurotoxicity being derived states.
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影响因子：
3.3
作者：
Calvete, Juan J.;Sanz, Libia;Moura-Da-Silva, Ana M.
通讯作者：
Moura-Da-Silva, Ana M.
影响因子：
3.7
作者：
Jansa SA;Voss RS
通讯作者：
Voss RS
影响因子：
4.4
作者：
Angulo, Yamileth;Escolano, Jose;Calvete, Juan J.
通讯作者：
Calvete, Juan J.
影响因子：
9.2
作者：
Dowell, Noah L.;Giorgianni, Matt W.;Kassner, Victoria A.;Selegue, Jane E.;Sanchez, Elda E.;Carroll, Sean B.
通讯作者：
Carroll, Sean B.
影响因子：
2.8
作者：
GLENN, JL;STRAIGHT, RC
通讯作者：
STRAIGHT, RC