Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh.
Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh.
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DOI：
10.1111/j.1651-2227.2009.01292.x
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Arifeen SE
中科院分区：
文献类型：
--
作者：
Moore SE;Prentice AM;Wagatsuma Y;Fulford AJ;Collinson AC;Raqib R;Vahter M;Persson LA;Arifeen SE
目的是评估营养状况和环境暴露对孟加拉国农村Matlab地区婴儿胸腺发育的影响。在一项旨在改善母婴健康的联合干预措施的随机研究中出生的Nmax 2094名婴儿队列中，通过超声检查评估了出生时以及8、24和52周龄时的胸腺体积（胸腺指数，TI）。还收集了关于出生体重、婴儿人体测量和喂养状况的数据。在所有年龄段，TI与婴儿体重呈正相关，与测量月份密切相关。纯母乳喂养持续时间越长，52周时TI越大。出生时和8周时的TI与出生体重呈正相关，但到24周和52周时，当调整婴儿体重时，这种影响不再存在。胸腺大小不受产前母亲补充或社会经济地位的影响，但与怀孕期间的砷暴露有关。在孟加拉国农村的婴儿中，胸腺发育受到生命早期营养和环境暴露的影响。这些发现的长期功能影响值得进一步研究。
The aim was to assess the impact of nutritional status and environmental exposures on infant thymic development in the rural Matlab region of Bangladesh. In a cohort of Nmax 2094 infants born during a randomized study of combined interventions to improve maternal and infant health, thymic volume (thymic index, TI) was assessed by ultrasonography at birth and at 8, 24 and 52 weeks of age. Data on birth weight, infant anthropometry and feeding status were also collected. At all ages, TI was positively associated with infant weight and strongly associated with the month of measurement. Longer duration of exclusive breastfeeding resulted in a larger TI at 52 weeks. TI at birth and at 8 weeks correlated positively with birth weight, but by 24 and 52 weeks and when adjusted for infant weight this effect was no longer present. Thymic size was not affected by pre-natal maternal supplementation or by socioeconomic status but was correlated to arsenic exposure during pregnancy. In this population of rural Bangladeshi infants, thymic development is influenced by both nutritional and environmental exposures early in life. The long-term functional implications of these findings warrant further investigation.
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影响因子：
10.4
作者：
Fangstrom, Britta;Moore, Sophie;Nermell, Barbro;Kuenstl, Linda;Goessler, Walter;Grander, Margaretha;Kabir, Iqbal;Palm, Brita;El Arifeen, Shams;Vahter, Marie
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3.8
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作者：
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通讯作者：
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5
作者：
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通讯作者：
Ekstrom, Eva-Charlotte
影响因子：
6.7
作者：
Savino W
通讯作者：
Savino W