Endocrinal metabolic regulation on the skeletal system in post-menopausal women.
Endocrinal metabolic regulation on the skeletal system in post-menopausal women.
复制标题
DOI：
10.3389/fphys.2022.1052429
复制
发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
骨质疏松症是一种常见的内分泌疾病，其特征在于慢性骨丢失状况。两性异形在骨质疏松症的发病率中是普遍存在的，绝经后妇女受到严重影响。包括雌激素在内的性腺性激素是骨量的重要调节剂;因此，这些激素的丢失会导致骨骼周转失衡，从而导致骨质疏松症。雌激素可通过降低成骨细胞活性和增强破骨细胞生成来影响骨形成和骨吸收。此外，雌激素是全身代谢的有效调节剂。最近的研究提供了线索，雌激素对骨的影响也可能涉及骨细胞代谢和生物能量潜力的改变。虽然尚未研究性腺激素改变骨细胞细胞内代谢能力的直接影响，但文献中有先例表明这会发生并导致绝经后骨质流失。这篇综述的目的是作为一个透视片，详细介绍了性腺激素调节骨细胞代谢潜力的前瞻性作用。
Osteoporosis is a common endocrinologic disorder characterized as a chronic bone loss condition. Sexual dimorphism is ubiquitous in the incidence of osteoporosis with post-menopausal women being acutely affected. Gonadal sex hormones including estrogen act as crucial regulators of bone mass; therefore, loss of such hormones leads to an imbalance in skeletal turnover leading to osteoporosis. Estrogen can influence both bone formation as well as resorption by reducing osteoblast activity and enhancing osteoclastogenesis. Additionally, estrogen is a potent regulator of systemic metabolism. Recent studies have provided clues that estrogenic effect on bone might also involve alterations in bone cell metabolism and bioenergetic potential. While direct effects of gonadal hormones ability to alter intracellular metabolism of bone cells has not been studied, there is precedence within the literature that this is occurring and contributing to post-menopausal bone loss. This review aims to serve as a perspective piece detailing the prospective role of gonadal hormones regulating bone cell metabolic potential.
登录
查看更多内容
影响因子：
4
作者：
Cooper, C.;Cole, Z. A.;Holroyd, C. R.;Earl, S. C.;Harvey, N. C.;Dennison, E. M.;Melton, L. J.;Cummings, S. R.;Kanis, J. A.
通讯作者：
Kanis, J. A.
影响因子：
6
作者：
通讯作者：
--
影响因子：
5.2
作者：
通讯作者：
--
影响因子：
4.1
作者：
ADAMEK, G;FELIX, R;FLEISCH, H
通讯作者：
FLEISCH, H
影响因子：
4.2
作者：
Alemany M
通讯作者：
Alemany M