Serum transfer of collagen-induced arthritis in mice.
Serum transfer of collagen-induced arthritis in mice.
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胶原诱导的小鼠关节炎的血清转移。
DOI：
10.1084/jem.158.2.378
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发表时间：
1983-08-01
期刊：
影响因子：
--
通讯作者：
Dixon FJ
中科院分区：
文献类型：
--
作者：
Stuart JM;Dixon FJ
用本地鸡ⅱ型胶原免疫DBA/1小鼠可在4-5周后形成多发性关节炎。这些小鼠的血清中含有高水平的抗胶原抗体，其血清中的免疫球蛋白浓缩物将关节炎转移给未免疫的受体。组织病理学上，这种被动转移性关节炎类似于免疫供者的早期疾病。免疫荧光研究表明，IgG和C3沉积在关节表面，而不是在关节炎关节的滑膜组织。转移的，同位素标记的抗胶原抗体迅速定位到四肢和其他含软骨组织。当转移浓缩物被施用于抗关节炎菌株时，它们也患上了关节炎。事实上，从胶原诱导的关节炎大鼠身上提取的免疫球蛋白浓缩物将关节炎转移到了幼年小鼠身上。转移到B10所需的浓缩物量。在转移前4周用胶原蛋白免疫D2抗性小鼠。虽然免疫对关节炎的易感性与H-2有关，但这些研究清楚地表明，关节炎的被动转移取决于注射特异性抗体，而不是其他宿主因素。
Immunization of DBA/1 mice with native chick type II collagen resulted in development of polyarthritis 4-5 wk later. Sera of these mice contained high levels of anticollagen antibodies, and immunoglobulin concentrates of their sera transferred arthritis to unimmunized recipients. Histopathologically, this passively transferred arthritis resembled the early disease of immunized donors. Immunofluorescence studies demonstrated the deposition of IgG and C3 on the articular surface but not in synovial tissue of arthritic joints. Transferred, isotopically labeled anticollagen antibodies rapidly localized to the limbs and to other cartilage-containing tissues. When transfer concentrate was administered to arthritis-resistant strains, they also developed arthritis. Indeed, immunoglobulin concentrates from rats with collagen-induced arthritis transferred arthritis to naive mice. The amount of concentrate required for transfer to B10.D2 resistant mice was reduced by immunizing them with collagen 4 wk before transfer. Although susceptibility to arthritis from immunization is H-2 linked, these studies clearly demonstrate that passive transfer of arthritis depends upon injection of specific antibody and not on other host factors.
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影响因子：
1.2
作者：
HASHIDA, R;TERATO, K;NAGAI, Y
通讯作者：
NAGAI, Y
DOI：
10.1159/000229376
发表时间：
1963-01-01
期刊：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
影响因子：
--
作者：
STEFFEN, C;TIMPL, R
通讯作者：
TIMPL, R
影响因子：
15.3
作者：
STUART, JM;CREMER, MA;KANG, AH
通讯作者：
KANG, AH
影响因子：
--
作者：
THEOFILOPOULOS, AN;CARSON, DA;VAUGHAN, JH
通讯作者：
VAUGHAN, JH
大鼠的耳软骨炎。用II型胶原蛋白诱导的复发多发性炎的实验模型。
影响因子：
15.3
作者：
Cremer, M A;Pitcock, J A;Stuart, J M;Kang, A H;Townes, A S
通讯作者：
Townes, A S