Measurement of tumour size with mammography, sonography and magnetic resonance imaging as compared to histological tumour size in primary breast cancer.
Measurement of tumour size with mammography, sonography and magnetic resonance imaging as compared to histological tumour size in primary breast cancer.
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DOI：
10.1186/1471-2407-13-328
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发表时间：
2013-07-05
期刊：
影响因子：
3.8
通讯作者：
Hahn M
中科院分区：
文献类型：
--
作者：
Gruber IV;Rueckert M;Kagan KO;Staebler A;Siegmann KC;Hartkopf A;Wallwiener D;Hahn M
乳腺癌的肿瘤大小影响治疗决策。本研究的目的是评价使用乳腺X线摄影、超声检查和磁共振成像（MRI）测量原发性乳腺癌的大小，从而确定哪种成像方法最准确地对应于组织学结果的大小。对121例原发性乳腺癌患者的资料进行回顾性分析。结果分为“导管原位癌（DCIS）"、浸润性导管癌（IDC）+导管原位癌（DCIS）"、“浸润性导管癌（IDC）"、“浸润性小叶癌（ILC）”和“其他肿瘤”（管状、髓样、粘液性和乳头状乳腺癌）。在每种情况下，选择最大肿瘤直径作为尺寸参考。Bland-Altman分析用于确定成像肿瘤大小与组织病理学肿瘤大小相关的程度。超声检查发现肿瘤大小被显著低估，尤其是IDC + DCIS、IDC和ILC肿瘤组。超声大小和实际组织学肿瘤大小之间的最大差异发现与浸润性小叶乳腺癌。乳腺摄影和组织学测量之间无显著差异。MRI高估肿瘤大小，但无显著性差异，且在IDC + DCIS和ILC的大小方面优于其他成像技术上级。组织学亚型应包括在计划手术的成像解释中，以尽可能准确地估计组织学肿瘤大小。
Tumour size in breast cancer influences therapeutic decisions. The purpose of this study was to evaluate sizing of primary breast cancer using mammography, sonography and magnetic resonance imaging (MRI) and thereby establish which imaging method most accurately corresponds with the size of the histological result. Data from 121 patients with primary breast cancer were analysed in a retrospective study. The results were divided into the groups “ductal carcinoma in situ (DCIS)”, invasive ductal carcinoma (IDC) + ductal carcinoma in situ (DCIS)”, “invasive ductal carcinoma (IDC)”, “invasive lobular carcinoma (ILC)” and “other tumours” (tubular, medullary, mucinous and papillary breast cancer). The largest tumour diameter was chosen as the sizing reference in each case. Bland-Altman analysis was used to determine to what extent the imaging tumour size correlated with the histopathological tumour sizes. Tumour size was found to be significantly underestimated with sonography, especially for the tumour groups IDC + DCIS, IDC and ILC. The greatest difference between sonographic sizing and actual histological tumour size was found with invasive lobular breast cancer. There was no significant difference between mammographic and histological sizing. MRI overestimated non-significantly the tumour size and is superior to the other imaging techniques in sizing of IDC + DCIS and ILC. The histological subtype should be included in imaging interpretation for planning surgery in order to estimate the histological tumour size as accurately as possible.
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影响因子：
2.7
作者：
Ohlinger, R.;Frese, H.;Grunwald, S.
通讯作者：
Grunwald, S.
影响因子：
3
作者：
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影响因子：
2.1
作者：
Shoma, A;Moutamed, A;Abdelwahab, A
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Abdelwahab, A
影响因子：
1.3
作者：
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通讯作者：
Skjorten, F
影响因子：
3.4
作者：
Varga, D.;Woeckel, A.;Sauer, G.
通讯作者：
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