Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
Analysis on Association of a SNP in the Chicken OBR Gene with Growth and Body Composition Traits
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鸡OBR基因SNP与生长和体成分性状的关联分析
DOI：
10.5713/ajas.2006.1706
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发表时间：
2006-09
期刊：
影响因子：
--
通讯作者：
Z.L.Gu
中科院分区：
文献类型：
--
作者：
Y. Wang;H. Li;Y.D. Zhang;Z.L.Gu
瘦素受体（Leptin receptor，OBR）是I类细胞因子受体家族的成员。它主要通过JAK/STAT信号传导途径，在调节机体能量储存和代谢中起重要作用。本研究旨在研究OBR基因对鸡生长和体成分的影响。使用针对腹部脂肪或针对腹部脂肪不同选择的肉鸡品系。使用来自公共基因组域的鸡基因组序列设计OBR基因中外显子9区域的引物。在该人群中发现一个C/A单核苷酸多态性（SNP），并鉴定出3种基因型（AA、AB和BB）。结果表明，OBR基因多态性与腹脂重、腹脂率等肥满度性状相关。本研究提示OBR基因或其连锁基因对鸡脂肪沉积有影响。
Leptin receptor (OBR) is a member of the class I cytokine receptor family. It signals mainly via the JAK/STAT pathway and plays an important role in regulating body energy storage and metabolism. This study was designed to investigate the effects of the OBR gene on chicken growth and body composition. Broiler lines selected divergently for or against abdominal fat were used. Primers for the exon9-region in the OBR gene were designed using chicken genomic sequences from the public genome domain. A C/A single nucleotide polymorphism (SNP) was found and its three genotypes (AA, AB and BB) were identified in this population. The results showed that the OBR polymorphism was associated with fatness traits, such as abdominal fat weight and abdominal fat percentage. This research suggests that OBR or a linked gene has effect on fat deposition in the chicken.
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DOI：
--
发表时间：
2002-05
期刊：
Yi chuan = Hereditas
影响因子：
--
作者：
Z. Gu;Jianguo Zhao;Hui Li;H. Meng;Qigui Wang;Qing-hua Wang;Da-Hai Zhu
通讯作者：
Z. Gu;Jianguo Zhao;Hui Li;H. Meng;Qigui Wang;Qing-hua Wang;Da-Hai Zhu
影响因子：
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Yiying Zhang;R. Proenca;M. Maffei;M. Barone;L. Leopold;J. Friedman
影响因子：
64.5
作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
Blakemore, AIF
MC4R 基因多态性与鸡生长和身体成分性状的关联
DOI：
10.5713/ajas.2006.763
发表时间：
2006-06-01
期刊：
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
影响因子：
--
作者：
Li, CY;Li, H
通讯作者：
Li, H