Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans.
Primary Epstein-Barr virus infection does not erode preexisting CD8⁺ T cell memory in humans.
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DOI：
10.1084/jem.20112401
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发表时间：
2012-03-12
期刊：
影响因子：
--
通讯作者：
Hogquist KA
中科院分区：
文献类型：
--
作者：
Odumade OA;Knight JA;Schmeling DO;Masopust D;Balfour HH Jr;Hogquist KA
在原发性EB病毒感染期间，对流感病毒或巨细胞病毒特异性的人CD8+ T细胞的旁观者活化不会导致预先存在的记忆T细胞损耗。急性EB病毒（EBV）感染导致年轻人异常强烈的CD8+ T细胞反应。基于小鼠研究，预测这种应答将导致预先存在的记忆对异源感染如甲型流感（Flu）和巨细胞病毒（CMV）的损耗。此外，许多研究试图定义淋巴细胞增多症，发生在急性EBV感染的人，但目前还不清楚是否旁观者T细胞有助于it.To解决这些问题，我们进行了纵向前瞻性研究原发性EBV感染的人。在急性EBV感染期间，既存的CMV特异性和Flu特异性记忆性CD8+ T细胞均显示出旁观者激活的迹象，包括颗粒酶B的上调。然而，它们通常不扩增，这表明与急性EBV感染相关的严重CD8+淋巴细胞增多主要由EBV特异性T细胞组成。重要的是，CMV特异性T细胞和流感特异性T细胞的数量在急性EBV感染前后是相当的。这些数据支持这样的概念，即在人类中，稳健的CD8+ T细胞应答产生了新的记忆CD8+ T细胞小生境，而基本上没有耗尽预先存在的对异源感染的记忆。
Bystander activation of human CD8+ T cells specific for influenza or cytomegalovirus during primary Epstein-Barr virus infection does not result in preexisting memory T cell attrition. Acute Epstein-Barr virus (EBV) infection results in an unusually robust CD8+ T cell response in young adults. Based on mouse studies, such a response would be predicted to result in attrition of preexisting memory to heterologous infections like influenza A (Flu) and cytomegalovirus (CMV). Furthermore, many studies have attempted to define the lymphocytosis that occurs during acute EBV infection in humans, but it is unclear whether bystander T cells contribute to it. To address these issues, we performed a longitudinal prospective study of primary EBV infection in humans. During acute EBV infection, both preexisting CMV- and Flu-specific memory CD8+ T cells showed signs of bystander activation, including up-regulation of granzyme B. However, they generally did not expand, suggesting that the profound CD8+ lymphocytosis associated with acute EBV infection is composed largely of EBV-specific T cells. Importantly, the numbers of CMV- and Flu-specific T cells were comparable before and after acute EBV infection. The data support the concept that, in humans, a robust CD8+ T cell response creates a new memory CD8+ T cell niche without substantially depleting preexisting memory for heterologous infections.
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影响因子：
2.2
作者：
Prabhu, A;Warwick, M;Mathur, A
通讯作者：
Mathur, A
影响因子：
4.4
作者：
Smith, DK;Dudani, R;Sad, S
通讯作者：
Sad, S
DOI：
10.4049/jimmunol.1003949
发表时间：
2011-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Schmidt NW;Harty JT
通讯作者：
Harty JT
DOI：
10.1128/cdli.2.2.209-213.1995
发表时间：
1995-03-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
HORNEF, MW;WAGNER, HJ;KIRCHNER, H
通讯作者：
KIRCHNER, H
影响因子：
5.4
作者：
McNally, JM;Zarozinski, CC;Welsh, RM
通讯作者：
Welsh, RM