Myocardial blood volume is associated with myocardial oxygen consumption: an experimental study with cardiac magnetic resonance in a canine model.
Myocardial blood volume is associated with myocardial oxygen consumption: an experimental study with cardiac magnetic resonance in a canine model.
复制标题
DOI：
10.1016/j.jcmg.2009.07.010
复制
发表时间：
2009-11
影响因子：
14
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
McCommis, Kyle S.;Zhang, Haosen;Goldstein, Thomas A.;Misselwitz, Bernd;Abendschein, Dana R.;Gropler, Robert J.;Zheng, Jie
关键词：
评价心血管MR（CMR）测定局部心肌灌注和氧代谢的可行性，并评价心肌血容量（MBV）对氧供应的作用。冠状动脉疾病表现为心肌氧供需失衡。我们已经开发了相关的CMR方法来确定药物充血期间心肌血流量（MBF）和MBV与耗氧量（MVO 2）的关系。对21只杂种犬进行了研究，对近端左前降支（LAD）冠状动脉施加不同程度的狭窄。采用CMR首过灌注法测定MBF和MBV，采用BOLD效应法测定氧摄取分数（OEF），采用Fick定律测定MVO 2。在静息状态下，以及在潘生丁诱导的血管舒张或多巴酚丁胺诱导的充血期间进行MR成像。然后评价心肌灌注和氧合的区域差异。双嘧达莫和多巴酚丁胺均使正常心肌MBF增加145-200%，MBV增加50-80%。正如预期的那样，多巴酚丁胺（~175%）比双嘧达莫（~40%）更显著地增加MVO 2。冠状动脉狭窄导致LAD对向狭窄区域和左回旋支对向远端区域的MBF、MBV和MVO 2衰减。线性回归分析表明，MBV储备似乎更相关的MVO 2储备多巴酚丁胺应力比MBF储备，特别是在狭窄区域。相反，MBF储备似乎更相关的MVO 2储备在潘生丁，虽然这些差异都不显着。CMR对心肌灌注和氧合的无创性评价有助于直接监测局部心肌缺血，并为更好地了解微血管病理生理学提供了有价值的工具。这些技术可以补充延迟增强和室壁运动分析方案，使MRI成为心肌缺血成像的有价值的“一站式商店”。
To evaluate the feasibility of cardiovascular MR (CMR) to determine regional myocardial perfusion and O2 metabolism, and assess the role of myocardial blood volume (MBV) on oxygen supply. Coronary artery disease presents as an imbalance of myocardial oxygen supply and demand. We have developed relevant CMR methods to determine the relationship of myocardial blood flow (MBF) and MBV to oxygen consumption (MVO2) during pharmacologic hyperemia. Twenty-one mongrel dogs were studied with varying stenosis severities imposed on the proximal left anterior descending (LAD) coronary artery. MBF and MBV were determined by CMR first-pass perfusion, while the oxygen extraction fraction (OEF) and MVO2 were determined by the myocardial Blood-Oxygen-Level-Dependent (BOLD) effect and Fick’s law, respectively. MR imaging was performed at rest, and during either dipyridamole-induced vasodilation or dobutamine-induced hyperemia. Regional differences in myocardial perfusion and oxygenation were then evaluated. Dipyridamole and dobutamine both led to 145–200% increases in MBF and 50–80% increases in MBV in normal perfused myocardium. As expected, MVO2 increased more significantly with dobutamine (~175%) than dipyridamole (~40%). Coronary stenosis resulted in an attenuation of MBF, MBV, and MVO2 in both the LAD-subtended stenosis region and the left circumflex subtended remote region. Liner regression analysis showed that MBV reserve appears to be more correlated with MVO2 reserve during dobutamine stress than MBF reserve, particularly in the stenotic regions. Conversely, MBF reserve appears to be more correlated with MVO2 reserve during dipyridamole, although neither of these differences was significant. Noninvasive evaluation of both myocardial perfusion and oxygenation by CMR facilitates direct monitoring of regional myocardial ischemia and provides a valuable tool for better understanding microvascular pathophysiology. These techniques could complement delayed enhancement and wall motion analysis protocols, making MRI a valuable “one-stop shop” for imaging of myocardial ischemia.
登录
查看更多内容
影响因子：
3.3
作者：
Zheng, J;Wang, JH;Woodard, PK
通讯作者：
Woodard, PK
DOI：
10.1016/s1053-0770(03)00156-3
发表时间：
2003-08-01
影响因子：
2.8
作者：
Hoffman, WE;Albrecht, RF;Jonjev, ZS
通讯作者：
Jonjev, ZS
DOI：
10.1152/ajpheart.01383.2007
发表时间：
2008-06-01
影响因子：
4.8
作者：
Jameel, Mohammad N.;Wang, Xiaohong;Zhang, Jianyi
通讯作者：
Zhang, Jianyi
影响因子：
3.3
作者：
Goldstein, Thomas A.;Jerosch-Herold, Michael;Zheng, Jie
通讯作者：
Zheng, Jie
DOI：
10.1067/mje.2002.121275
发表时间：
2002-09-01
影响因子：
6.5
作者：
Le, DE;Bin, JP;Kaul, S
通讯作者：
Kaul, S