Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial.
Effects of Dietary Sugar Reduction on Biomarkers of Cardiometabolic Health in Latino Youth: Secondary Analyses from a Randomized Controlled Trial.
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DOI：
10.3390/nu15153338
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发表时间：
2023-07-27
期刊：
影响因子：
5.9
通讯作者：
Goran, Michael I.
中科院分区：
文献类型：
--
作者：
Schmidt, Kelsey A.;Mokhtari, Pari;Holzhausen, Elizabeth A.;Alderete, Tanya L.;Allayee, Hooman;Nayak, Krishna S.;Sinatra, Frank R.;Pickering, Trevor A.;Mack, Wendy;Kohli, Rohit;Goran, Michael I.
儿童肥胖症和心脏代谢疾病对少数群体的影响不成比例。减少糖摄入是一种很有前途的预防策略，糖摄入量增加与心脏代谢疾病的不利生物标志物之间存在一致的横截面关联。很少有试验测试儿科降糖干预措施的有效性。因此，在一项平行设计试验中，我们将肥胖的拉丁裔青年（BMI ≥第95百分位数）[n = 105; 14.8岁]随机分为对照组（标准饮食建议）或降糖组（临床干预，目标是游离糖的卡路里≤10%），为期12周。结果包括通过2小时频繁采样口服葡萄糖耐量试验评估的葡萄糖耐量及其决定因素的变化、空腹血脂谱（总胆固醇、HDL、LDL、甘油三酯、胆固醇：HDL）和炎症标志物（CRP、IL-6、TNF-α）。与对照组相比，干预组的游离糖摄入量减少[分别为11.5%至7.3% vs. 13.9%至10.7%（能量%），p = 0.02]，但对任何关注的结果均无影响（pall > 0.07）。然而，一项探索性分析显示，糖减少与随机化无关，与改善的口服处置指数（p < 0.001）、甘油三酯（p = 0.049）和TNF-α（p = 0.02）相关。饮食糖减少可能有可能通过改善β细胞功能，血清甘油三酯和炎症标志物来降低患有肥胖的拉丁美洲青少年的慢性疾病风险。
Pediatric obesity and cardiometabolic disease disproportionately impact minority communities. Sugar reduction is a promising prevention strategy with consistent cross-sectional associations of increased sugar consumption with unfavorable biomarkers of cardiometabolic disease. Few trials have tested the efficacy of pediatric sugar reduction interventions. Therefore, in a parallel-design trial, we randomized Latino youth with obesity (BMI ≥ 95th percentile) [n = 105; 14.8 years] to control (standard diet advice) or sugar reduction (clinical intervention with a goal of ≤10% of calories from free sugar) for 12-weeks. Outcomes included changes in glucose tolerance and its determinants as assessed by a 2-h frequently sample oral glucose tolerance test, fasting serum lipid profile (total cholesterol, HDL, LDL, triglycerides, cholesterol:HDL), and inflammatory markers (CRP, IL-6, TNF-). Free sugar intake decreased in the intervention group compared to the control group [11.5% to 7.3% vs. 13.9% to 10.7% (% Energy), respectively, p = 0.02], but there were no effects on any outcome of interest (pall > 0.07). However, an exploratory analysis revealed that sugar reduction, independent of randomization, was associated with an improved Oral-disposition index (p < 0.001), triglycerides (p = 0.049), and TNF- (p = 0.02). Dietary sugar reduction may have the potential to reduce chronic disease risks through improvements in beta-cell function, serum triglycerides, and inflammatory markers in Latino adolescents with obesity.
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