Non-additive microbial community responses to environmental complexity.
Non-additive microbial community responses to environmental complexity.
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DOI：
10.1038/s41467-021-22426-3
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发表时间：
2021-04-22
影响因子：
16.6
通讯作者：
Segrè D
中科院分区：
文献类型：
--
作者：
Pacheco AR;Osborne ML;Segrè D
环境组成是微生物群动态的一个主要决定因素，尽管人们对此知之甚少。在这里，我们问一般原则是否支配微生物群落如何随着环境分子数量的增加而增长和多样性的扩大。通过在体外组装数百个合成联合体，我们发现生长产量可以保持不变，或者在环境复杂的情况下以非相加的方式增加。相反，分类多样性往往比预期的要低得多。为了更好地理解这些偏差，我们制定了环境之间上位性交互的指标，并使用它们将我们的结果与使用实验参数化的消费者资源模型模拟的社区进行比较。我们发现，关键的代谢和生态因素，包括物种相似性、专门化程度和代谢相互作用，调节了观察到的非加性，并控制了群落对资源库组合的反应。我们的结果表明，仅有环境的复杂性不足以维持群落的多样性，并为设计和控制微生物生态系统提供了实用的指导。微生物群落特性在日益复杂的资源组合下如何变化仍不清楚。在这里，作者研究了数百个合成联合体，以确定控制增长和分类多样性如何随环境复杂性变化的因素。
Environmental composition is a major, though poorly understood, determinant of microbiome dynamics. Here we ask whether general principles govern how microbial community growth yield and diversity scale with an increasing number of environmental molecules. By assembling hundreds of synthetic consortia in vitro, we find that growth yield can remain constant or increase in a non-additive manner with environmental complexity. Conversely, taxonomic diversity is often much lower than expected. To better understand these deviations, we formulate metrics for epistatic interactions between environments and use them to compare our results to communities simulated with experimentally-parametrized consumer resource models. We find that key metabolic and ecological factors, including species similarity, degree of specialization, and metabolic interactions, modulate the observed non-additivity and govern the response of communities to combinations of resource pools. Our results demonstrate that environmental complexity alone is not sufficient for maintaining community diversity, and provide practical guidance for designing and controlling microbial ecosystems. How microbial community properties change under increasingly complex combinations of resources remains unclear. Here, the authors studied hundreds of synthetic consortia to identify the factors that govern how growth and taxonomic diversity scale with environmental complexity.
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影响因子：
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