A novel cascaded energy conversion system inducing efficient and precise cancer therapy.
A novel cascaded energy conversion system inducing efficient and precise cancer therapy.
复制标题
DOI：
10.1016/j.bioactmat.2022.07.007
复制
发表时间：
2023-03
影响因子：
18.9
通讯作者：
Ji, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Kang, Yong;Kong, Na;Ou, Meitong;Wang, Ying;Xiao, Qicai;Mei, Lin;Liu, Bing;Chen, Liqun;Zeng, Xiaobin;Ji, Xiaoyuan
关键词：
基于能量转换的癌症治疗，如光热疗法（PTT，光热能转换）和光动力疗法（PDT，光化学能转换）在临床前研究中引起了广泛关注。然而，PTT 相关的高温对周围组织的损伤以及 PDT 应用光的浅穿透阻碍了进一步的高级临床实践。在这里，我们开发了一种基于热电材料构建p-n异质结（SrTiO3/Cu2Se纳米板）的热电疗法（TET），其原理是光-热-电-化学能量转换。在辐照和自然冷却引起的温度梯度（35-45 oC）后，构建了自建电场，从而促进了块体 SrTiO3 和 Cu2Se 中的电荷分离。重要的是，SrTiO3（n型）和Cu2Se（p型）之间的接触构造了另一个界面电场，进一步引导分离的电荷重新定位到SrTiO3和Cu2Se的表面上。两个电场的形成最大限度地减少了电荷重组的可能性。值得注意的是，在分离的电子和空穴的催化下，O2和H2O产生高性能的超氧自由基和羟基自由基，导致细胞内ROS爆发和癌细胞凋亡，而对周围组织没有明显损害。在异质结中构建体电场和界面电场以改善电荷分离和转移也有望为各种应用提供稳健的策略。提供了一种基于光-热-电-化学能量转换原理的热电疗法。两个自建电场引导电子空穴对定向有序分离。温和温度梯度下的热电疗法诱导癌细胞凋亡而不损害正常组织。
Cancer therapies based on energy conversion, such as photothermal therapy (PTT, light-to-thermal energy conversion) and photodynamic therapy (PDT, light-to-chemical energy conversion) have attracted extensive attention in preclinical research. However, the PTT-related hyperthermia damage to surrounding tissues and shallow penetration of PDT-applied light prevent further advanced clinical practices. Here, we developed a thermoelectric therapy (TET) based on thermoelectric materials constructed p-n heterojunction (SrTiO3/Cu2Se nanoplates) on the principle of light-thermal-electricity-chemical energy conversion. Upon irradiation and natural cooling-induced the temperature gradient (35–45 oC), a self-build-in electric field was constructed and thereby facilitated charges separation in bulk SrTiO3 and Cu2Se. Importantly, the contact between SrTiO3 (n type) and Cu2Se (p type) constructed another interfacial electric field, further guiding the separated charges to re-locate onto the surfaces of SrTiO3 and Cu2Se. The formation of two electric fields minimized probability of charges recombination. Of note, high-performance superoxide radicals and hydroxyl radicals’ generation from O2 and H2O under catalyzation by separated electrons and holes, led to intracellular ROS burst and cancer cells apoptosis without apparent damage to surrounding tissues. Construction of bulk and interfacial electric fields in heterojunction for improving charges separation and transfer is also expected to provide a robust strategy for diverse applications. A thermoelectric therapy based on the principle of light-heat-electricity-chemical energy conversion has been provided. Two self-build-in electric fields guide electron-hole pairs directional and ordered separation. Thermoelectric therapy under mild temperature gradient induces cancer cells apoptosis without damage to normal tissues.
登录
查看更多内容
影响因子：
18.9
作者：
Nie W;Yu T;Liu X;Wang B;Li T;Wu Y;Zhou X;Ma L;Lin Y;Qian Z;Gao X
通讯作者：
Gao X
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
17.1
作者：
Deng, Yexin;Luo, Zhe;Ye, Peide D.
通讯作者：
Ye, Peide D.
影响因子：
13.3
作者：
Kang, Yong;Lei, Lei;Ji, Xiaoyuan
通讯作者：
Ji, Xiaoyuan
用于 NIR-II/光声成像引导光热引发一氧化氮/光热治疗的半导体聚合物纳米治疗学
影响因子：
14
作者：
Li, Jie;Jiang, Rongcui;Fan, Quli
通讯作者：
Fan, Quli