Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors.
Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors.
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两种妊娠队列中与胎儿生长有关的产前PFA和社会心理应激暴露：将环境混合物方法应用于化学和非化学应激源。
DOI：
10.1016/j.envint.2022.107238
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发表时间：
2022-05
影响因子：
11.8
通讯作者：
Morello-Frosch, Rachel
中科院分区：
文献类型：
--
作者：
Eick, Stephanie M.;Enright, Elizabeth A.;Padula, Amy M.;Aung, Max;Geiger, Sarah D.;Cushing, Lara;Trowbridge, Jessica;Keil, Alexander P.;Baek, Hyoung Gee;Smith, Sabrina;Park, June-Soo;DeMicco, Erin;Schantz, Susan L.;Woodruff, Tracey J.;Morello-Frosch, Rachel
产前暴露于单独的全氟烷基和多氟烷基物质（PFAS）和心理社会压力与胎儿生长减少有关。研究表明，化学和非化学应激源对胎儿生长的累积或联合影响。然而，很少有研究将PFAS和非化学应激源作为一种混合物来研究，这种混合物更好地反映了真实的生活暴露模式。我们研究了联合协会PFAS，感知压力，抑郁症和胎儿生长使用两种方法开发的暴露混合物。怀孕的参与者被纳入我们身体中的化学物质队列和伊利诺伊州儿童发展研究，它们共同组成了ECHO.CA.IL队列。先前在妊娠中期母体血清样本中测量了7个PFAS，并进行了自然对数转换以进行分析。感知压力和抑郁进行了评估，使用自我报告的有效问卷，这是转换为t分数，使用有效的方法。使用分位数g计算和贝叶斯核机器回归（BKMR）来评估PFAS、感知压力和抑郁t评分与出生体重z评分之间的联合关联（N = 876）。个体PFAS、抑郁和感知压力t评分与出生体重z评分呈负相关。使用分位数g计算，所有PFAS、感知压力和抑郁t评分同时增加一个四分位数与出生体重z评分轻微降低相关（每四分位数增加的平均变化=-0.09，95%置信区间=-0.21，0.03）。BKMR同样表明，累积PFAS和压力t评分与较低的出生体重z评分适度相关。在这两种方法中，联合关联似乎分布在多次暴露中，而不是由于单次暴露。我们的研究是第一个使用混合方法来研究化学和非化学应激对胎儿生长的联合影响的研究。我们发现，PFAS，感知压力和抑郁症的组合是适度相关的出生体重较低的z分数，这支持了先前的研究表明，化学和非化学压力源共同与不良的健康结果。
Prenatal exposure to individual per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors have been associated with reductions in fetal growth. Studies suggest cumulative or joint effects of chemical and non-chemical stressors on fetal growth. However, few studies have examined PFAS and non-chemical stressors together as a mixture, which better reflects real life exposure patterns. We examined joint associations between PFAS, perceived stress, and depression, and fetal growth using two approaches developed for exposure mixtures. Pregnant participants were enrolled in the Chemicals in Our Bodies cohort and Illinois Kids Development Study, which together make up the ECHO.CA.IL cohort. Seven PFAS were previously measured in 2nd trimester maternal serum samples and were natural log transformed for analyses. Perceived stress and depression were assessed using self-reported validated questionnaires, which were converted to t-scores using validated methods. Quantile g-computation and Bayesian kernel machine regression (BKMR) were used to assess joint associations between PFAS, perceived stress and depression t-scores and birthweight z-scores (N = 876). Individual PFAS, depression and perceived stress t-scores were negatively correlated with birthweight z-scores. Using quantile g-computation, a simultaneous one quartile increase in all PFAS, perceived stress and depression t-scores was associated with a slight reduction in birthweight z-scores (mean change per quartile increase = −0.09, 95% confidence interval = −0.21, 0.03). BKMR similarly indicated that cumulative PFAS and stress t-scores were modestly associated with lower birthweight z-scores. Across both methods, the joint association appeared to be distributed across multiple exposures rather than due to a single exposure. Our study is one of the first to examine the joint effects of chemical and non-chemical stressors on fetal growth using mixture methods. We found that PFAS, perceived stress, and depression in combination were modestly associated were lower birthweight z-scores, which supports prior studies indicating that chemical and non-chemical stressors are jointly associated with adverse health outcomes.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1097/ee9.0000000000000095
发表时间：
2020-06
期刊：
Environmental epidemiology (Philadelphia, Pa.)
影响因子：
--
作者：
Dzierlenga MW;Crawford L;Longnecker MP
通讯作者：
Longnecker MP
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
6
作者：
Eick, Stephanie M.;Hom Thepaksorn, Elizabeth K.;Morello-Frosch, Rachel
通讯作者：
Morello-Frosch, Rachel
影响因子：
11.8
作者：
Coker E;Chevrier J;Rauch S;Bradman A;Obida M;Crause M;Bornman R;Eskenazi B
通讯作者：
Eskenazi B