Adult human neurogenesis: from microscopy to magnetic resonance imaging.
Adult human neurogenesis: from microscopy to magnetic resonance imaging.
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DOI：
10.3389/fnins.2011.00047
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发表时间：
2011
影响因子：
4.3
通讯作者：
Maletic-Savatic M
中科院分区：
文献类型：
--
作者：
Sierra A;Encinas JM;Maletic-Savatic M
神经干细胞存在于成年人大脑的明确区域，并且能够在整个生命周期中产生新的神经元。在啮齿类动物中，新生的神经元参与嗅觉以及某些形式的记忆和学习。在人类中，成年人神经发生的功能相关性正在研究中，特别是其在各种脑疾病的发病机制中的意义。成年人大脑中的神经发生是通过利用直接从啮齿动物研究中引入的方法来发现的，例如死后或活检组织中增殖和细胞类型特异性生物标志物的免疫组织学检测。然而，在绝大多数情况下，这些方法不支持纵向研究;因此，不能测试推定的干细胞在不同疾病条件下形成新神经元的能力。最近，专门开发了用于检测和定量活体人脑中神经干细胞的新技术。这些技术依赖于磁共振成像的使用，在世界各地的医院都有。虽然这些新方法需要在啮齿动物和灵长类动物中进一步验证，但它们有可能测试成年人神经发生对健康和疾病中大脑功能的贡献。本文综述了目前对成人神经发生的认识。我们首先回顾了不同的方法可用于评估人类神经发生，无论是在体内和体外，然后评估成人神经发生在人类疾病的变化。
Neural stem cells reside in well-defined areas of the adult human brain and are capable of generating new neurons throughout the life span. In rodents, it is well established that the new born neurons are involved in olfaction as well as in certain forms of memory and learning. In humans, the functional relevance of adult human neurogenesis is being investigated, in particular its implication in the etiopathology of a variety of brain disorders. Adult neurogenesis in the human brain was discovered by utilizing methodologies directly imported from the rodent research, such as immunohistological detection of proliferation and cell-type specific biomarkers in postmortem or biopsy tissue. However, in the vast majority of cases, these methods do not support longitudinal studies; thus, the capacity of the putative stem cells to form new neurons under different disease conditions cannot be tested. More recently, new technologies have been specifically developed for the detection and quantification of neural stem cells in the living human brain. These technologies rely on the use of magnetic resonance imaging, available in hospitals worldwide. Although they require further validation in rodents and primates, these new methods hold the potential to test the contribution of adult human neurogenesis to brain function in both health and disease. This review reports on the current knowledge on adult human neurogenesis. We first review the different methods available to assess human neurogenesis, both ex vivo and in vivo and then appraise the changes of adult neurogenesis in human diseases.
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DOI：
10.1016/j.devbrainres.2004.03.021
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bédard, A;Parent, A
通讯作者：
Parent, A
影响因子：
6.2
作者：
Danilov, Alexandre I.;Gomes-Leal, Walace;Lindvall, Olle
通讯作者：
Lindvall, Olle
影响因子：
3.3
作者：
Cha, S;Johnson, G;Turnbull, DH
通讯作者：
Turnbull, DH
影响因子：
6.1
作者：
Crespel, A;Rigau, V;Lerner-Natoli, M
通讯作者：
Lerner-Natoli, M
抗抑郁药会增加人海马中的神经祖细胞。
影响因子：
7.6
作者：
Boldrini, Maura;Underwood, Mark D.;Hen, Rene;Rosoklija, Gorazd B.;Dwork, Andrew J.;Mann, J. John;Arango, Victoria
通讯作者：
Arango, Victoria