Cortical gray matter structure in boys with Klinefelter syndrome.
Cortical gray matter structure in boys with Klinefelter syndrome.
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DOI：
10.1016/j.pscychresns.2021.111299
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发表时间：
2021-07-30
期刊：
影响因子：
--
通讯作者：
Reiss AL
中科院分区：
文献类型：
--
作者：
Foland-Ross LC;Gil M;Shrestha SB;Chromik LC;Hong D;Reiss AL
Klinefelter综合征(KS，47，XXY)是一种常见的男性性染色体非整倍体，与广泛的认知、社会和情感特征有关。然而，这些症状的神经基础尚不清楚。对19例青春期前或青春期早期KS男童(11.5±1.8岁)和22例发育正常(8.1±2.3岁)男童的脑结构进行了基于表面的灰质体积、厚度和表面积分析。KS组的男孩在睾酮替代疗法方面的治疗很天真。与TD组相比，KS组的脑岛和背内侧前额叶皮质体积减小，而顶叶、枕叶和运动区的体积增加。对基于表面的指标的进一步检查表明，KS相关的体积增加是由厚度的增加驱动的，而KS相关的体积的减少与表面积的减少有关。探索性分析表明了大脑结构和行为之间的相关性，为这种情况的认知和情感症状的神经基础提供了初步支持。综上所述，这些数据增加了对KS神经解剖学表型的支持，并通过阐明引起体积变化的KS的精确神经解剖结构特征扩展了先前的研究。
Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males that is associated with a wide range of cognitive, social and emotional characteristics. The neural bases of these symptoms, however, are unclear. Brain structure in 19 pre- or early-pubertal boys with KS (11.5 ± 1.8 years) and 22 typically developing (control) boys (8.1 ± 2.3 years) was examined using surface-based analyses of cortical gray matter volume, thickness and surface area. Boys in the KS group were treatment-naïve with respect to testosterone replacement therapy. Reduced volume in the insula and dorsomedial prefrontal cortex was observed in the KS relative to the TD group, as well as increased volume in the parietal, occipital and motor regions. Further inspection of surface-based metrics indicated that whereas KS-associated increases in volume were driven by increases in thickness, KS-associated reductions in volume were associated with decreases in surface area. Exploratory analyses indicated correlations between brain structure and behavior, providing initial support for a neural basis of cognitive and emotional symptoms of this condition. Taken together, these data add support for a neuroanatomical phenotype of KS and extend previous studies through clarifying the precise neuroanatomical structural characteristics of that give rise to volumetric alterations.
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影响因子：
16.2
作者：
Geschwind DH;Rakic P
通讯作者：
Rakic P
影响因子：
3.7
作者：
Bramen, Jennifer E.;Hranilovich, Jennifer A.;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
影响因子：
8
作者：
Bruining, Hilgo;Swaab, Hanna;van Engeland, Herman
通讯作者：
van Engeland, Herman
DOI：
10.1523/jneurosci.4682-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
通讯作者：
Van Essen D
灵长类同皮质神经元密度和数量的系统性平衡梯度。
影响因子：
2.9
作者：
Cahalane DJ;Charvet CJ;Finlay BL
通讯作者：
Finlay BL