Neural Correlates of Attentional Modulation of Prepulse Inhibition.
Neural Correlates of Attentional Modulation of Prepulse Inhibition.
复制标题
前脉冲抑制的注意力调节的神经相关性
DOI：
10.3389/fnhum.2021.649566
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发表时间：
2021
影响因子：
2.9
通讯作者：
Meng Q
中科院分区：
文献类型：
--
作者：
Lei M;Ding Y;Meng Q
前脉冲抑制（PPI）是指当强烈的惊吓刺激之前不久（20-500 ms）有一个弱的非惊吓刺激（前脉冲）时，惊吓反射的抑制。虽然PPI的主要神经相关位于脑干，但先前的研究表明，PPI可以由注意力自上而下地调节。然而，在以前的注意-前脉冲PPI范式中，只有连续的前脉冲而不是离散的前脉冲（20 ms）可以引起注意调制的PPI。此外，注意增强PPI和前脉冲信号的早期皮质表征的变化之间的关系尚不清楚。本研究开发了一种新的注意-前脉冲PPI任务，当离散前脉冲设置为150 ms，导联间隔为270 ms时，发现注意前脉冲的PPI大于忽略前脉冲的PPI。此外，前脉冲的早期皮层表征（N1/P2复合体）显示被关注和被忽略的前脉冲之间的分离。N1成分被定向注意增强，且N1成分的注意增强与PPI的注意增强呈正相关，而P2成分不受注意调节的影响。因此，对前脉冲的直接注意可以增强PPI和前脉冲信号（N1）的早期皮层表示。
Prepulse inhibition (PPI) refers to the suppression of the startle reflex when the intense startling stimulus is shortly (20–500 ms) preceded by a weak non-startling stimulus (prepulse). Although the main neural correlates of PPI lie in the brainstem, previous research has revealed that PPI can be top-down modulated by attention. However, in the previous attend-to-prepulse PPI paradigm, only continuous prepulse but not discrete prepulse (20 ms) could elicit attentional modulation of PPI. Also, the relationship between the attentional enhancement of PPI and the changes in early cortical representations of prepulse signals is unclear. This study develops a novel attend-to-prepulse PPI task, when the discrete prepulse is set at 150 ms at a lead interval of 270 ms, and reveals that the PPI with attended prepulse is larger than the PPI with ignored prepulse. In addition, the early cortical representations (N1/P2 complex) of the prepulse show dissociation between the attended and ignored prepulse. N1 component is enhanced by directed attention, and the attentional increase of the N1 component is positively correlated with the attentional enhancement of PPI, whereas the P2 component is not affected by attentional modulation. Thus, directed attention to the prepulse can enhance both PPI and the early cortical representation of the prepulse signal (N1).
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