Microscale magnetic field modulation using rapidly patterned soft magnetic microstructures.
Microscale magnetic field modulation using rapidly patterned soft magnetic microstructures.
复制标题
使用快速图案化软磁微结构进行微尺度磁场调制
DOI：
10.1039/d1ra06173a
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发表时间：
2021-10-25
期刊：
影响因子：
3.9
通讯作者：
Chen, Yan
中科院分区：
文献类型：
--
作者：
Shen, Fengshan;Yu, Yan;Li, Yuexuan;Feng, Hongtao;Wu, Tianzhun;Chen, Yan
局部调制磁场分布的能力是基于磁力的微流体装置中有效操纵的先决条件。在这里，我们报告了一种简单、稳健、快速的用于局部调制磁场的磁性微结构的制造方法。在所提出的方法中，利用由聚乙二醇二丙烯酸酯（PEGDA）基质中的羰基铁微粒组成的光敏磁性复合材料来光刻制造磁性微结构。首先评估复合材料的磁性行为，然后在几分钟内在载玻片上制作各种复杂的图案。为了证明磁性微结构作为磁场集中器的能力，设计并制造了与外部磁场具有不同方向的磁性微结构，例如方形阵列和网格状磁性微结构。对这种磁性微结构的调制磁场进行了数值分析，然后通过捕获磁性水凝胶珠进行实验验证。此外，将磁性标记的细胞应用于磁性微结构，以证明通过磁性引导在表现出增强磁场梯度的区域中限制细胞的可能性。总体而言，所提出的方法有助于简单快速地制造用于磁场微尺度调制的软磁微结构，这在基于磁力的微流体技术中表现出巨大的应用潜力。
The ability to locally modulate the magnetic field distribution is a prerequisite for efficient manipulation in magnetic force-based microfluidic devices. Here, we report a simple, robust, and fast fabrication method of magnetic microstructures for locally modulating magnetic fields. In the proposed method, a photosensitive magnetic composite consisting of carbonyl-iron microparticles in a poly(ethylene glycol) diacrylate (PEGDA) matrix was utilized to photolithographically fabricate magnetic microstructures. The magnetic behavior of the composite was first evaluated, and then various complicated patterns were fabricated on a glass slide within a few minutes. To demonstrate the capability of magnetic microstructures as a magnetic field concentrator, magnetic microstructures with different orientations to the external magnetic field were designed and fabricated, such as square arrays and grid-like magnetic microstructures. The modulated magnetic fields from such magnetic microstructures were numerically analyzed and then experimentally validated by trapping magnetic hydrogel beads. Further, the magnetically labeled cells were applied to the magnetic microstructures to prove the possibility of cell confinement via magnetic guidance in regions that exhibit enhanced magnetic field gradients. Overall, the proposed approach facilitates simple and fast fabrication of soft magnetic microstructures for microscale modulation of magnetic fields, which exhibits an immense application potential in magnetic force-based microfluidic techniques.
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