Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder.
Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder.
复制标题
DOI：
10.1016/j.plefa.2009.12.002
复制
发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Yao JK
中科院分区：
文献类型：
--
作者：
Conklin SM;Runyan CA;Leonard S;Reddy RD;Muldoon MF;Yao JK
越来越多的证据发现，患有情感障碍(如单相和双相抑郁)的人外周膜脂肪酸相对缺乏。在这里，我们试图调查死后前扣带回皮质(BA24)内的死后脑脂肪酸是否随着死亡时存在的严重抑郁症而变化。用毛细管气相色谱法测定了抑郁症组(n=12)和无精神疾病终身史的对照组(n=14)的脂肪酸。与对照组相比，抑郁组的大量饱和脂肪酸和多不饱和脂肪酸的浓度显著降低，包括n-3和n-6脂肪酸。此外，抑郁症组的死亡年龄与n-3脂肪酸途径中的前体(或代谢物)显著相关，而对照组则没有。在n-6脂肪酸家族中，患者组20：3(n-6)/18：2(n-6)的比例高于对照组，而20：4(n-6)/20：3(n-6)的比例相对较低。患者的年龄与20：4(n-6)和22：6(n-3)的比例呈显著负相关，而对照组则没有。综上所述，22：6(n-3)的减少可能至少部分是由于20：5(n-3)的形成减少所致，该20：5(n-3)是由20：4(n-3)通过Δ5去饱和酶反应得到的。目前对死后脑组织的发现提出了这样一种可能性，即20：4(n-6)到22：6(n-3)的比例增加可能为我们提供抑郁症的生物标记物。未来的研究应该进一步探讨这些关系。
Accumulating evidence finds a relative deficiency of peripheral membrane fatty acids in persons with affective disorders such as unipolar and bipolar depression. Here we sought to investigate whether postmortem brain fatty acids within the anterior cingulate cortex (BA 24) varied according to the presence of major depression at the time of death. Using capillary gas chromatography we measured fatty acids in a depressed group (n=12), and in a control group without lifetime history of psychiatric diagnosis (n=14). Compared to the control group, the depressed group showed significantly lower concentrations of numerous saturated and polyunsaturated fatty acids including both the n-3 and n-6 fatty acids. Additionally, significant correlations between age at death and precursor (or metabolites) in the n-3 fatty acid pathway were demonstrated in the depressed group but not in control subjects. In the n-6 fatty acid family, the ratio of 20:3(n-6)/18:2(n-6) was higher in patients than in control groups, whereas the ratio of 20:4(n-6)/20:3(n-6) was relatively decreased in patients. Lastly, a significant negative correlation between age and the ratio of 20:4(n-6) to 22:6(n-3) was found in patients, but not in controls. Taken together, decreases in 22:6(n-3) may be caused, at least in part, by the diminished formation of 20:5(n-3), which is derived from 20:4(n-3) through a Δ5 desaturase reaction. The present findings from postmortem brain tissue raise the possibility that an increased ratio of 20:4(n-6) to 22:6(n-3) may provide us with a biomarker for depression. Future research should further investigate these relationships.
登录
查看更多内容
影响因子：
3.3
作者：
HARDY, JA;WESTER, P;ERIKSSON, A
通讯作者：
ERIKSSON, A
影响因子：
6.5
作者：
Kodas, E;Vancassel, S;Chalon, S
通讯作者：
Chalon, S
影响因子：
3.7
作者：
Gianaros, PJ;Derbyshire, SWG;Jennings, JR
通讯作者：
Jennings, JR
影响因子：
6.5
作者：
DeMar, JC;Ma, KZ;Rapoport, SI
通讯作者：
Rapoport, SI
影响因子：
10.6
作者：
Frasure-Smith, N;Lespérance, F;Julien, P
通讯作者：
Julien, P