Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment.
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DOI：
10.1007/s00213-019-05448-0
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发表时间：
2021-05
影响因子：
3.4
通讯作者：
Harmer CJ
中科院分区：
文献类型：
--
作者：
Godlewska BR;Harmer CJ
抑郁症是全世界致残的主要原因，改善其治疗是未来规划的核心研究重点。心理和生物过程的观点发生了变化，从认为它们是分开的到相互补充的，这为抑郁症的病理机制和治疗方式的作用带来了新的视角。这篇综述提出了一个理论模型，该模型结合了这种新颖的方法，即抗抑郁作用的认知神经心理学假说。该模型表明，抗抑郁药物治疗在抗抑郁治疗早期减少了情绪显著信息加工的负性偏差，从而导致治疗后期的临床显着情绪改善。本文讨论了消极情感偏见在抑郁症的发展和对抗抑郁药物治疗的反应中的作用。它还讨论了该模型是否可以应用于其他抗抑郁干预措施及其潜在的转化价值，包括治疗选择，反应预测和药物开发。
Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as separate to complementing one another, has introduced new perspectives on pathological mechanisms of depression and treatment mode of action. This review presents a theoretical model that incorporated this novel approach, the cognitive neuropsychological hypothesis of antidepressant action. This model proposes that antidepressant treatments decrease the negative bias in the processing of emotionally salient information early in the course of antidepressant treatment, which leads to the clinically significant mood improvement later in treatment. The paper discusses the role of negative affective biases in the development of depression and response to antidepressant treatments. It also discusses whether the model can be applied to other antidepressant interventions and its potential translational value, including treatment choice, prediction of response and drug development.
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影响因子：
2.6
作者：
De Raedt, Rudi;Leyman, Lemke;Dannlowski, Udo
通讯作者：
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影响因子：
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DOI：
10.1016/s0140-6736(17)32802-7
发表时间：
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期刊：
Lancet (London, England)
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