Identifying key questions in the ecology and evolution of cancer.
Identifying key questions in the ecology and evolution of cancer.
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DOI：
10.1111/eva.13190
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发表时间：
2021-04
影响因子：
4.1
通讯作者：
Ujvari B
中科院分区：
文献类型：
--
作者：
Dujon AM;Aktipis A;Alix-Panabières C;Amend SR;Boddy AM;Brown JS;Capp JP;DeGregori J;Ewald P;Gatenby R;Gerlinger M;Giraudeau M;Hamede RK;Hansen E;Kareva I;Maley CC;Marusyk A;McGranahan N;Metzger MJ;Nedelcu AM;Noble R;Nunney L;Pienta KJ;Polyak K;Pujol P;Read AF;Roche B;Sebens S;Solary E;Staňková K;Swain Ewald H;Thomas F;Ujvari B
在过去的50年里，将进化和生态学原理应用于癌症预防和治疗，以及认识到癌症是自然界的一种选择力量，已经获得了动力。在最初的理论方法结合了跨学科领域的知识之后，很明显，使用生态进化框架对于理解癌症至关重要。我们现在正处于一个关键时刻，积累的证据开始引导学科的未来方向，并使我们能够支持仍然需要解决的关键挑战。在这里，我们的目标是评估该领域目前的进展，并提出未来的研究方向。首先，我们总结了癌症研究领域，到目前为止，已经吸收了生态和进化的原则到他们的方法，并说明他们的关键重要性。然后，我们召集了33位专家，确定了84个关键问题，围绕9个主要主题组织，为未来的研究奠定基础。我们强调迫切需要扩大研究方向的组合，以刺激新的方法在肿瘤学和生态学和进化科学的接口。我们的结论是，为了有效地解决当前和未来的癌症问题，利用生态学，进化和癌症领域的专业知识进行渐进和有效的跨学科合作至关重要。
The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco‐evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed. Here, we aim to assess current advancements in the field and to suggest future directions for research. First, we summarize cancer research areas that, so far, have assimilated ecological and evolutionary principles into their approaches and illustrate their key importance. Then, we assembled 33 experts and identified 84 key questions, organized around nine major themes, to pave the foundations for research to come. We highlight the urgent need for broadening the portfolio of research directions to stimulate novel approaches at the interface of oncology and ecological and evolutionary sciences. We conclude that progressive and efficient cross‐disciplinary collaborations that draw on the expertise of the fields of ecology, evolution and cancer are essential in order to efficiently address current and future questions about cancer.
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影响因子：
5.8
作者：
Capp JP;Thomas F
通讯作者：
Thomas F
影响因子：
16
作者：
Blake, William J.;Balazsi, Gbor;Collins, James J.
通讯作者：
Collins, James J.
影响因子：
4.1
作者：
Aktipis CA;Nesse RM
通讯作者：
Nesse RM
影响因子：
--
作者：
Albuquerque TAF;Drummond do Val L;Doherty A;de Magalhães JP
通讯作者：
de Magalhães JP
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影响因子：
3.7
作者：
Chen J;Guo SX;Liu PG
通讯作者：
Liu PG