Estimation of the hemoglobin glycation rate constant.
Estimation of the hemoglobin glycation rate constant.
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DOI:
10.1038/s41598-020-80024-7
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发表时间:
2021-01-13
影响因子:
4.6
通讯作者:
Koga M
中科院分区:
文献类型:
--
作者:
Kameyama M;Okumiya T;Tokuhiro S;Matsumura Y;Matsui H;Ono Y;Iwasaka T;Hiratani K;Koga M
In a previous study, a method of obtaining mean erythrocyte age () from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ( dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving from erythrocyte creatine (EC). Utilizing these formulae, this study aimed to determine a more accurate estimate of . One hundred and seven subjects including 31 patients with hemolytic anemia and 76 subjects without anemia were included in this study. EC and HbA1c data were analyzed, and using HbA1c, AG and the newly-derived constant, were compared to using traditional in three patients whose data were taken from previous case studies. A value of dL/mg/day was determined for . using HbA1c, AG and were found to no be significantly different (paired t-test, ) to using traditional . enables the estimation of from HbA1c and AG.
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