Estimation of the hemoglobin glycation rate constant.

Estimation of the hemoglobin glycation rate constant.
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DOI:
10.1038/s41598-020-80024-7
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发表时间:
2021-01-13
期刊:
影响因子:
4.6
通讯作者:
Koga M
Koga M
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kameyama M;Okumiya T;Tokuhiro S;Matsumura Y;Matsui H;Ono Y;Iwasaka T;Hiratani K;Koga M

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在先前的研究中,提出了一种从HbA 1c和平均血糖(AG)获得平均红细胞年龄()的方法。然而,该模型所需的血红蛋白糖化常数(dL/mg/天)的真实值尚未得到很好的表征。另一项研究还提出了一种从红细胞中提取肌酸(EC)的方法。利用这些公式,本研究旨在确定一个更准确的估计。本研究纳入了107例受试者,包括31例溶血性贫血患者和76例无贫血的受试者。分析EC和HbA 1c数据,并使用HbA 1c,AG和新推导的常数,比较使用传统的3例患者的数据来自以前的病例研究。确定的值为dL/mg/天。 使用HbA 1c,AG,发现与使用传统方法无显著差异(配对t检验)。 能够从HbA 1c和AG估计。
In a previous study, a method of obtaining mean erythrocyte age () from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ( dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving from erythrocyte creatine (EC). Utilizing these formulae, this study aimed to determine a more accurate estimate of . One hundred and seven subjects including 31 patients with hemolytic anemia and 76 subjects without anemia were included in this study. EC and HbA1c data were analyzed, and using HbA1c, AG and the newly-derived constant, were compared to using traditional in three patients whose data were taken from previous case studies. A value of dL/mg/day was determined for . using HbA1c, AG and were found to no be significantly different (paired t-test, ) to using traditional . enables the estimation of from HbA1c and AG.
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