Neurons along the auditory pathway exhibit a hierarchical organization of prediction error.
Neurons along the auditory pathway exhibit a hierarchical organization of prediction error.
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DOI：
10.1038/s41467-017-02038-6
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发表时间：
2017-12-15
影响因子：
16.6
通讯作者：
Malmierca MS
中科院分区：
文献类型：
--
作者：
Parras GG;Nieto-Diego J;Carbajal GV;Valdés-Baizabal C;Escera C;Malmierca MS
感知的特征是神经区域之间的预测和预测误差信号的相互交换。然而，这种感觉失配反应和分级预测处理之间的关系还没有在听觉通路的神经元水平上得到证实。我们记录了麻醉大鼠和清醒小鼠不同听觉中枢的单个神经元活动，同时播放一系列声音，旨在将由于预测误差而引起的反应与由于适应效应引起的反应分开。在这里，我们报告了预测误差是沿着中央听觉通路分层组织的。这些预测误差信号可以在皮质下区域检测到，并随着信号向听觉皮质移动而增加，这反过来又显示出大规模的失配潜力。最后，单个听觉神经元的预测活动是皮层下加工水平自动异常检测的基础。这些结果表明，预测误差是单个听神经元反应的基本成分。知觉可以通过预测编码来解释，但目前还不清楚这一理论如何应用于单神经元水平。这里，作者描述了听觉通路上单个神经元是如何编码和检测听觉模式的，证明了单个听觉神经元存在预测误差。
Perception is characterized by a reciprocal exchange of predictions and prediction error signals between neural regions. However, the relationship between such sensory mismatch responses and hierarchical predictive processing has not yet been demonstrated at the neuronal level in the auditory pathway. We recorded single-neuron activity from different auditory centers in anaesthetized rats and awake mice while animals were played a sequence of sounds, designed to separate the responses due to prediction error from those due to adaptation effects. Here we report that prediction error is organized hierarchically along the central auditory pathway. These prediction error signals are detectable in subcortical regions and increase as the signals move towards auditory cortex, which in turn demonstrates a large-scale mismatch potential. Finally, the predictive activity of single auditory neurons underlies automatic deviance detection at subcortical levels of processing. These results demonstrate that prediction error is a fundamental component of singly auditory neuron responses. Perception can be explained by predictive coding, but it is unclear how this theory applies at the single-neuron level. Here, authors describe how auditory patterns are encoded and detected by single neurons along the auditory pathway, demonstrating that prediction error exists in single auditory neurons.
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影响因子：
3.5
作者：
Ayala YA;Pérez-González D;Duque D;Nelken I;Malmierca MS
通讯作者：
Malmierca MS
影响因子：
3.5
作者：
Ayala YA;Malmierca MS
通讯作者：
Malmierca MS
影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
影响因子：
4.6
作者：
Ayala YA;Udeh A;Dutta K;Bishop D;Malmierca MS;Oliver DL
通讯作者：
Oliver DL
影响因子：
2.5
作者：
Eliades, Steven J.;Crone, Nathan E.;Boatman-Reich, Dana
通讯作者：
Boatman-Reich, Dana