Essential oils and their constituents as anticancer agents: a mechanistic view.
Essential oils and their constituents as anticancer agents: a mechanistic view.
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DOI：
10.1155/2014/154106
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发表时间：
2014
影响因子：
--
通讯作者：
Mittal S
中科院分区：
文献类型：
--
作者：
Gautam N;Mantha AK;Mittal S
探索天然植物产品作为一种选择来寻找新的化学实体作为抗癌剂是发展最快的研究领域之一。最近，在过去的十年中，人们一直在研究精油在癌症治疗中的应用，本综述试图收集和记录表明精油及其成分作为抗癌剂的现有研究。本文综述了迄今为止从不同植物物种中提取的近130项关于精油及其成分抗癌潜力的研究，这些研究分为精油及其成分的体内和体外研究。本综述还深入介绍了不同类型肿瘤的治疗策略中不同EOs及其成分的各种作用机制。目前的研究表明，EOs及其成分通过多种途径和机制发挥作用，包括细胞凋亡、细胞周期阻滞、抗转移和抗血管生成、活性氧和氮（ROS/RNS）水平升高、DNA修复调节等，以证明其在癌细胞中的抗增殖活性。还讨论了EOs及其成分对肿瘤抑制蛋白（p53和Akt）、转录因子（NF-κB和AP-1）、mapk通路以及SOD、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽还原酶等解毒酶的影响。
Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitro and in vivo studies for EOs and their constituents. This review also highlights in-depth various mechanisms of action of different EOs and their constituents reported in the treatment strategies for different types of cancer. The current review indicates that EOs and their constituents act by multiple pathways and mechanisms involving apoptosis, cell cycle arrest, antimetastatic and antiangiogenic, increased levels of reactive oxygen and nitrogen species (ROS/RNS), DNA repair modulation, and others to demonstrate their antiproliferative activity in the cancer cell. The effect of EOs and their constituents on tumour suppressor proteins (p53 and Akt), transcription factors (NF-κB and AP-1), MAPK-pathway, and detoxification enzymes like SOD, catalase, glutathione peroxidase, and glutathione reductase has also been discussed.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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