Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis.
Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis.
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动脉粥样硬化的分子影像研究：23年科学计量学和目视分析。
DOI：
10.3389/fbioe.2023.1152067
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发表时间：
2023
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
背景：心脑血管疾病是全球性的重大健康问题，动脉粥样硬化是主要病因。近年来，分子成像已广泛应用于多种疾病的诊断和治疗，包括动脉粥样硬化。大量事实表明，分子影像学在动脉粥样硬化的早期诊断和靶向治疗方面具有广阔的前景。目的：对近23年来发表的动脉粥样硬化分子影像学研究文献进行科学计量学分析，找出动脉粥样硬化分子影像学研究的关键进展、热点和新趋势。方法：从Web of Science Core Collection数据库中检索有关动脉粥样硬化分子成像的原始研究和综述。微软Excel 2021用于分析主要发现。利用CiteSpace、VOSviewer和一个科学计量在线平台对期刊和参考文献的共被引情况、关键词共现情况、国家/地区、机构和作者之间的协作情况进行可视化分析。结果：共纳入文献1755篇，作者795位，来自59个国家/地区的443家机构。美国是该领域发表论文数量和中心性最高的国家，共有810篇论文，中心性为0.38，哈佛大学发表论文最多（182篇）。Fayad， ZA是最多产的作者，发表了73篇论文，而LIBBY P的共被引次数最多（493次）。《CIRCULATION》是共被引频次最多的期刊，共被引频次为1411次，其次是ARTERIOSCL THROM VAS（1128次）。共被引文献分析发现8个聚类具有结构良好的网络（Q = 0.6439）和高可信度的聚类（S = 0.8865）。将关键词共现计算的所有研究分为“纳米粒子”、“磁共振成像”、“炎症”、“正电子发射断层扫描”和“超声”5类。热点话题主要集中在心血管疾病、造影剂、巨噬细胞、易损斑块、微泡等方面。氟化钠⁃PET、靶向给药、OCT、光声成像、ROS和氧化应激被认为是潜在的趋势。结论：动脉粥样硬化分子影像学研究已引起学术界的广泛关注，本文综述了该领域临床转化面临的挑战。目前的研究结果可以为资助机构和研究人员指明未来的方向。
Background: Cardiovascular and cerebrovascular diseases are major global health problems, and the main cause is atherosclerosis. Recently, molecular imaging has been widely employed in the diagnosis and therapeutic applications of a variety of diseases, including atherosclerosis. Substantive facts have announced that molecular imaging has broad prospects in the early diagnosis and targeted treatment of atherosclerosis. Objective: We conducted a scientometric analysis of the scientific publications over the past 23 years on molecular imaging research in atherosclerosis, so as to identify the key progress, hotspots, and emerging trends. Methods: Original research and reviews regarding molecular imaging in atherosclerosis were retrieved from the Web of Science Core Collection database. Microsoft Excel 2021 was used to analyze the main findings. CiteSpace, VOSviewer, and a scientometric online platform were used to perform visualization analysis of the co-citation of journals and references, co-occurrence of keywords, and collaboration between countries/regions, institutions, and authors. Results: A total of 1755 publications were finally included, which were published by 795 authors in 443 institutions from 59 countries/regions. The United States was the top country in terms of the number and centrality of publications in this domain, with 810 papers and a centrality of 0.38, and Harvard University published the largest number of articles (182). Fayad, ZA was the most productive author, with 73 papers, while LIBBY P had the most co-citations (493). CIRCULATION was the top co-cited journal with a frequency of 1,411, followed by ARTERIOSCL THROM VAS (1,128). The co-citation references analysis identified eight clusters with a well-structured network (Q = 0.6439) and highly convincing clustering (S = 0.8865). All the studies calculated by keyword co-occurrence were divided into five clusters: “nanoparticle,” “magnetic resonance imaging,” “inflammation,” “positron emission tomography,” and “ultrasonography”. Hot topics mainly focused on cardiovascular disease, contrast media, macrophage, vulnerable plaque, and microbubbles. Sodium fluoride ⁃PET, targeted drug delivery, OCT, photoacoustic imaging, ROS, and oxidative stress were identified as the potential trends. Conclusion: Molecular imaging research in atherosclerosis has attracted extensive attention in academia, while the challenges of clinical transformation faced in this field have been described in this review. The findings of the present research can inform funding agencies and researchers toward future directions.
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影响因子：
16.1
作者：
Atukorale PU;Covarrubias G;Bauer L;Karathanasis E
通讯作者：
Karathanasis E
影响因子：
2.9
作者：
通讯作者：
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影响因子：
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作者：
Duan H;Iagaru A;Aparici CM
通讯作者：
Aparici CM
影响因子：
5.6
作者：
Cheng, Kunming;Guo, Qiang;Shen, Zefeng;Yang, Weiguang;Wang, Yulin;Sun, Zaijie;Wu, Haiyang
通讯作者：
Wu, Haiyang
影响因子：
6.9
作者：
Park, Sung-Jin;Chan, Wan Ying;Ng, Michael;Chung, Yiu Cho;Chong, Tze Tec;Bhakoo, Kishore;Chan, Joyce M. S.
通讯作者：
Chan, Joyce M. S.