Profile of auditory information-processing deficits in schizophrenia.
Profile of auditory information-processing deficits in schizophrenia.
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DOI：
10.1016/j.psychres.2008.04.013
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发表时间：
2009-01-30
影响因子：
11.3
通讯作者：
Gur RE
中科院分区：
文献类型：
--
作者：
Turetsky BI;Bilker WB;Siegel SJ;Kohler CG;Gur RE
精神分裂症患者在几种不同的听觉 ERP 测量中表现出异常。目前尚不清楚这些异常现象如何相互关联，因为很少从同一样本中获得多种测量值。这项研究解决了两个相关问题：1）精神分裂症患者的特定听觉 ERP 测量是否有不同程度的受损？ 2）同一患者体内的异常现象是否同时聚集？在一次测试中，我们从 23 名精神分裂症患者和 22 名健康受试者中获得了 9 项听觉 ERP 测量值。分层倾斜因子分析显示，这些措施聚合为 4 个因子，每个因子主要加载于一个因子。观察患者缺陷的两个独立因素：N100/MMN 和 P3a/P3b。 N100/MMN 异常与失语和形式思维障碍症状相关。 P3a/P3b 异常与意志缺失、注意力障碍和妄想相关。我们得出的结论是，患者听觉皮层水平的早期感觉处理的不同 ERP 测量值同时存在缺陷。这些可能代表一个单一的差异缺陷，表明语言和言语处理受损背后的生理异常。这相对独立于介导认知刺激评估的较高皮质缺陷，并且是动机、注意力和现实测试缺陷的基础。这种 ERP 异常的多维分析可能有助于阐明精神分裂症的临床和遗传异质性。
Schizophrenia patients exhibit abnormalities in several different auditory ERP measures. It is unclear how these abnormalities relate to each other, since multiple measures are rarely acquired from the same sample. This study addressed two related questions: 1)Are specific auditory ERP measures differentially impaired in schizophrenia? 2)Do abnormalities co-aggregate within the same patients? Nine auditory ERP measures were acquired in a single testing session from 23 schizophrenia patients and 22 healthy subjects. Hierarchical oblique factor analysis revealed that these measures aggregated into 4 factors, with each loading primarily on a single factor. Patient deficits were observed for two independent factors: N100/MMN and P3a/P3b. N100/MMN abnormalities were associated with symptoms of alogia and formal thought disorder. P3a/P3b abnormalities were associated with avolition, attentional disturbances and delusions. We conclude that deficits in different ERP measures of early sensory processing at the level of the auditory cortex co-occur in patients. These likely represent a single differential deficit indexing the physiological abnormality underlying impaired language and verbal processing. This is relatively independent of a higher cortical deficit that mediates cognitive stimulus evaluation and underlies deficits in motivation, attention and reality testing. Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia.
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影响因子：
2.9
作者：
JAVITT, DC;STEINSCHNEIDER, M;AREZZO, JC
通讯作者：
AREZZO, JC
DOI：
10.1017/s1461145706007504
发表时间：
2007-12-01
影响因子：
4.8
作者：
Hammer, Trine-Bjoerg;Oranje, Bob;Glenthoj, Birte Y.
通讯作者：
Glenthoj, Birte Y.
影响因子：
4.5
作者：
Kumari, V;Soni, W;Sharma, T
通讯作者：
Sharma, T
影响因子：
10.6
作者：
Coburn, KL;Shillcutt, SD;Moore, NC
通讯作者：
Moore, NC
影响因子：
17.7
作者：
Light, GA;Geyer, MA;Braff, DL
通讯作者：
Braff, DL