Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.
Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.
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DOI：
10.1016/j.neuroimage.2020.117048
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发表时间：
2020-10-15
期刊：
影响因子：
5.7
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Spooner RK;Eastman JA;Wiesman AI;Wilson TW
感觉门控(SG)是一种神经生理现象，在这种现象中，对重复对中的第二个刺激的反应会减弱。这种对无关或冗余信息的过滤被认为是为了保存神经资源，以获得更多与行为相关的刺激，从而反映出感觉输入的功能抑制。开发一种实现最佳感觉输入抑制的SG范式需要研究人员考虑许多参数，如刺激强度、刺激对之间的时间以及每对刺激之间的刺激间间隔(ISI)。虽然这些因素已经被很好地定义为听觉门控的询问，但在躯体感觉领域引发最佳门控的精确参数还远未被了解。为了解决这一问题，我们使用脑磁图(MEG)研究了在每对相同的刺激中不同的ISI对门控的影响。具体地说，25名健康的年轻人接受了正中神经的成对脉冲电刺激，ISIS在100到1000毫秒(以100毫秒为增量)之间增加。重要的是，为了与以前对体感门控的研究相一致，我们评估了对体感刺激的时域和振荡神经反应。我们的结果表明，对于ISI为200-220ms的试验，体感输入的门控是最优的(即最佳抑制)，最小的门控比率和最优抑制的统计建模估计证明了这一点。重要的是，无论是使用振荡性神经活动还是诱发神经活动来计算SG，这都是正确的。有趣的是，使用峰值伽马(30-75赫兹)功率和频率计算的门控振荡度量显示出比使用时域神经反应计算的更健壮的门控(即更小的比率)，这表明高频振荡可能提供了更敏感的SG度量。这些发现对于开发最优的方案和分析管道以更高的灵敏度和准确性询问SG和抑制加工具有重要意义。
Sensory gating (SG) is a neurophysiological phenomenon whereby the response to the second stimulus in a repetitive pair is attenuated. This filtering of irrelevant or redundant information is thought to preserve neural resources for more behaviorally-relevant stimuli and thereby reflect the functional inhibition of sensory input. Developing a SG paradigm in which optimal suppression of sensory input is achieved requires investigators to consider numerous parameters such as stimulus intensity, time between stimulus pairs, and the inter-stimulus interval (ISI) within each pair. While these factors have been well defined for the interrogation of auditory gating, the precise parameters for eliciting optimal gating in the somatosensory domain are far less understood. To address this, we investigated the impact of varying the ISI within each identical pair of stimuli on gating using magnetoencephalography (MEG). Specifically, 25 healthy young adults underwent paired-pulse electrical stimulation of the median nerve with increasing ISIs between 100 and 1000 ms (in 100 ms increments). Importantly, for correspondence with previous studies of somatosensory gating, both time-domain and oscillatory neural responses to somatosensory stimulation were evaluated. Our results indicated that gating of somatosensory input was optimal (i.e., best suppression) for trials with an ISI of 200–220 ms, as evidenced by the smallest gating ratios and through statistical modeling estimations of optimal suppression. Importantly, this was true irrespective of whether oscillatory or evoked neural activity was used to calculate SG. Interestingly, oscillatory metrics of gating calculated using peak gamma (30–75 Hz) power and frequency revealed more robust gating (i.e., smaller ratios) than those calculated using time-domain neural responses, suggesting that high frequency oscillations may provide a more sensitive measure of SG. These findings have important implications for the development of optimal protocols and analysis pipelines to interrogate SG and inhibitory processing with a higher degree of sensitivity and accuracy.
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