Prefrontal cortex and impulsive decision making.

Prefrontal cortex and impulsive decision making.
复制标题

DOI:
10.1016/j.biopsych.2010.07.005
复制
发表时间:
2011-06-15
影响因子:
10.6
通讯作者:
Lee, Daeyeol
Lee, Daeyeol
中科院分区:
医学1区
文献类型:
--
作者:
Kim, Soyoun;Lee, Daeyeol

文献摘要

参考文献

被引文献

相似文献

冲动是指沿着某些时间维度进行次优调整的一组异质行为。冲动性跨期选择是指放弃大量但延迟的奖励并寻求较差但更直接的奖励的倾向,而当受试者未能抑制不适当的自动行为时,也会产生冲动性运动反应。此外,当在包括感知决策在内的各种行为中过分强调速度而不是准确性时,可能会产生冲动行为。尽管存在这种异质性,但前额皮质及其连接区域(例如基底神经节)在控制各种行为任务中的冲动行为方面发挥着重要作用。在这里,我们描述了最佳决策所需的计算的关键特征,以及它们的失败如何导致冲动行为。我们还回顾了神经影像学和单神经元记录研究中与冲动行为相关的神经机制的最新发现。经济学、心理学和神经科学的融合方法为更好地理解与冲动相关的行为障碍的本质提供了独特的前景。
Impulsivity refers to a set of heterogeneous behaviors that are tuned suboptimally along certain temporal dimensions. Impulsive inter-temporal choice refers to the tendency to forego a large but delayed reward and to seek an inferior but more immediate reward, whereas impulsive motor responses also result when the subjects fail to suppress inappropriate automatic behaviors. In addition, impulsive actions can be produced when too much emphasis is placed on speed rather than accuracy in a wide range of behaviors, including perceptual decision making. Despite this heterogeneous nature, the prefrontal cortex and its connected areas, such as the basal ganglia, play an important role in gating impulsive actions in a variety of behavioral tasks. Here, we describe key features of computations necessary for optimal decision making, and how their failures can lead to impulsive behaviors. We also review the recent findings from neuroimaging and single-neuron recording studies on the neural mechanisms related to impulsive behaviors. Converging approaches in economics, psychology, and neuroscience provide a unique vista for better understanding the nature of behavioral impairments associated with impulsivity.
DOI: 10.1126/science.1168450
发表时间: 2009-05-01
期刊: SCIENCE
影响因子: 56.9
作者:
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者: Rangel, Antonio
DOI: 10.1016/j.neuroimage.2008.11.004
发表时间: 2009-03-01
期刊: NeuroImage
影响因子: 5.7
作者:
Ballard K;Knutson B
通讯作者: Knutson B
DOI: 10.1073/pnas.96.14.8301
发表时间: 1999-07-06
影响因子: 11.1
作者:
Garavan, H;Ross, TJ;Stein, EA
通讯作者: Stein, EA
DOI: 10.1152/jn.1998.79.2.817
发表时间: 1998-02-01
影响因子: 2.5
作者:
Hanes, DP;Patterson, WF;Schall, JD
通讯作者: Schall, JD
DOI: 10.1073/pnas.0805903105
发表时间: 2008-11-11
影响因子: 11.1
作者:
Forstmann, Birte U.;Dutilh, Gilles;Wagenmaker, Eric-Jan
通讯作者: Wagenmaker, Eric-Jan