Applying a Conceptual Framework to Maximize the Participation of Diverse Populations in Cancer Clinical Trials.
Applying a Conceptual Framework to Maximize the Participation of Diverse Populations in Cancer Clinical Trials.
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DOI：
10.1016/bs.acr.2016.08.004
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发表时间：
2017
影响因子：
--
通讯作者：
Ford ME
中科院分区：
文献类型：
--
作者：
Napoles A;Cook E;Ginossar T;Knight KD;Ford ME
癌症临床试验中种族多样性人群的代表性不足导致了这项研究的风险和收益的不公平分配。使用案例研究的方法，我们应用了一个概念框架的因素与参与不同的人群在癌症临床试验的Jean福特博士和同事开发的，以增加理解的具体策略，障碍和推动者解决这些策略，导致在癌症临床研究中的种族和民族多样化的人群的累积显着的成功。结果表明，所介绍的研究之所以能够成功地吸引少数群体参与者，是因为制定和实施了多层次、多方面的战略，其中包括：在当地社区可以获得的文化和语言上适当的外联、教育和研究;支持关键利益攸关方、临床医生和服务少数群体社区的组织参与的基础设施;不同种族癌症幸存者的证词;提供医学口译服务;提供基础设施，促进照顾少数群体患者的临床医生参与临床研究。这些战略努力有效地解决了对试验的认识有限、缺乏参与机会以及接受参与癌症临床试验的问题。仔细关注癌症临床试验进行的背景和人群特征对于解决研究参与和癌症结果的差异是必要的。这些研究表明，少数人参与临床研究的进展需要有意识的努力，以克服所有三个阶段的障碍：意识，机会和接受参与。
The underrepresentation of ethnically diverse populations in cancer clinical trials results in the inequitable distribution of the risks and benefits of this research. Using a case study approach, we apply a conceptual framework of factors associated with the participation of diverse population groups in cancer clinical trials developed by Dr. Jean Ford and colleagues to increase understanding of the specific strategies, and barriers and promoters addressed by these strategies, that resulted in marked success in accrual of racially and ethnically diverse populations in cancer clinical research. Results indicate that the studies presented were able to successfully engage minority participants due to the creation and implementation of multi-level, multifaceted strategies that included: culturally and linguistically appropriate outreach, education, and research studies that were accessible in local communities; infrastructure to support engagement of key stakeholders, clinicians, and organizations serving minority communities; testimonials by ethnically diverse cancer survivors; availability of medical interpretation services; and providing infrastructure that facilitated the engagement in clinical research of clinicians who care for minority patient populations. These strategic efforts were effective in addressing limited awareness of trials, lack of opportunities to participate, and acceptance of engagement in cancer clinical trials. Careful attention to the context and population characteristics in which cancer clinical trials are conducted will be necessary to address disparities in research participation and cancer outcomes. These studies illustrate that progress on minority accrual into clinical research requires intentional efforts to overcome barriers at all three stages of the accrual process: awareness, opportunity and acceptance of participation.
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DOI：
10.1097/gim.0b013e3181cd6689
发表时间：
2010-02
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Bussey-Jones J;Garrett J;Henderson G;Moloney M;Blumenthal C;Corbie-Smith G
通讯作者：
Corbie-Smith G
影响因子：
2.7
作者：
Cook, ED;Moody-Thomas, S;Probstfield, JL
通讯作者：
Probstfield, JL
影响因子：
2.7
作者：
Cook, Elise D.;Arnold, Kathryn B.;Minasian, Lori M.
通讯作者：
Minasian, Lori M.
DOI：
10.1353/cpr.2012.0038
发表时间：
2012-09-01
影响因子：
1.1
作者：
Ford, Marvella;Wahlquist, Amy;Garrett-Mayer, Elizabeth
通讯作者：
Garrett-Mayer, Elizabeth
影响因子：
2.7
作者：
Leiter, Amanda;Diefenbach, Michael A.;Galsky, Matthew D.
通讯作者：
Galsky, Matthew D.