Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.
Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.
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IL-5 与趋化因子嗜酸细胞趋化因子协同作用，诱导体内嗜酸性粒细胞积聚。
DOI：
10.1084/jem.182.4.1169
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发表时间：
1995-10-01
影响因子：
15.3
通讯作者：
Williams, T. J.
中科院分区：
文献类型：
--
作者：
Collins, P. D.;Marleau, S.;Griffiths-Johnson, D. A.;Jose, P. J.;Williams, T. J.
设计实验以研究全身施用IL-5对由豚鼠皮内注射趋化因子eotaxin诱导的局部嗜酸性粒细胞积聚的影响。静脉注射白细胞介素-5（IL-5）可刺激i.d.注射嗜酸性粒细胞趋化因子和作为对照的白三烯B4。局部积聚的嗜酸性粒细胞数量与循环嗜酸性粒细胞的快速增加直接相关：静脉注射IL-5（18.3 pmol/kg）后1小时，循环嗜酸性粒细胞数量增加13倍。这种循环细胞的增加与冲洗股骨骨髓腔后回收的可置换嗜酸性粒细胞数量的减少相对应。皮内IL-5，在测试的剂量，没有诱导显着的嗜酸性粒细胞的积累。我们建议，这些实验模拟重要的早期特征的组织反应，局部过敏原暴露在致敏的个人，嗜酸性粒细胞趋化因子具有重要的局部作用，嗜酸性粒细胞招聘从血液微血管，和IL-5促进这一进程，作为一种激素，刺激释放到循环中的快速动员池的骨髓嗜酸性粒细胞。IL-5的这种作用将补充IL-5在较长时间过程中发挥作用的其他已确立的活性。
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the intradermal injection of the chemokine eotaxin in the guinea pig. Intravenous interleukin-5 (IL-5) stimulated a rapid and dramatic increase in the numbers of accumulating eosinophils induced by i.d.- injected eotaxin and, for comparison, leukotriene B4. The numbers of locally accumulating eosinophils correlated directly with a rapid increase in circulating eosinophils: circulating eosinophil numbers were 13-fold higher 1 h after intravenous IL-5 (18.3 pmol/kg). This increase in circulating cells corresponded with a reduction in the number of displaceable eosinophils recovered after flushing out the femur bone marrow cavity. Intradermal IL-5, at the doses tested, did not induce significant eosinophil accumulation. We propose that these experiments simulate important early features of the tissue response to local allergen exposure in a sensitized individual, with eosinophil chemoattractant chemokines having an important local role in eosinophil recruitment from blood microvessels, and IL-5 facilitating this process by acting remotely as a hormone to stimulate the release into the circulation of a rapidly mobilizable pool of bone marrow eosinophils. This action of IL-5 would be complementary to the other established activities of IL-5 that operate over a longer time course.
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DOI：
10.1164/ajrccm/144.6.1274
发表时间：
1991-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
SEDGWICK, JB;CALHOUN, WJ;BUSSE, WW
通讯作者：
BUSSE, WW
影响因子：
56.9
作者：
COFFMAN, RL;SEYMOUR, BWP;RENNICK, D
通讯作者：
RENNICK, D
影响因子：
15.9
作者：
HAMID, Q;AZZAWI, M;KAY, AB
通讯作者：
KAY, AB
影响因子：
6.5
作者：
HUDSON, G
通讯作者：
HUDSON, G
影响因子：
5.4
作者：
WANG, JM;RAMBALDI, A;MANTOVANI, A
通讯作者：
MANTOVANI, A