Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex.
Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex.
复制标题
距离调整的神经元驱动内侧肠系膜内侧的专业路径积分计算。
DOI：
10.1016/j.celrep.2021.109669
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发表时间：
2021-09-07
期刊：
影响因子：
8.8
通讯作者：
Giocomo LM
中科院分区：
文献类型：
--
作者：
Campbell MG;Attinger A;Ocko SA;Ganguli S;Giocomo LM
在导航过程中，动物使用路径整合和地标来估计它们的位置，这涉及到许多大脑区域。这些区域是否遵循专门的或普遍的线索整合原则仍然不完全清楚。我们将联合收割机与虚拟现实相结合，以量化三个导航相关区域中数千个神经元的线索整合：初级视觉皮层（V1），压后皮层（RSC）和内侧内嗅皮层（MEC）。与V1和RSC相比，MEC中路径整合对位置估计的影响更大，路径整合与地标之间的冲突更容易触发重映射。而MEC代码的位置前瞻性，V1代码的位置回顾性，和RSC是两者之间的中间。降低视觉对比度只在MEC中增加路径积分对位置估计的影响。这些特性在MEC神经元群体中最为明显，与网格细胞重叠，调整为在黑暗中跑距离。这些结果表明，与其他导航相关的皮层区域相比，路径整合在MEC中起着特殊的作用。坎贝尔等人使用Neuropixels记录在VR环境中导航的小鼠中显示MEC神经元比V1和RSC神经元更受路径整合的影响。这些差异是由MEC神经元的一个子集驱动的，这些神经元在黑暗中表现出模块化的距离调谐，让人想起网格细胞。
During navigation, animals estimate their position using path integration and landmarks, engaging many brain areas. Whether these areas follow specialized or universal cue integration principles remains incompletely understood. We combine electrophysiology with virtual reality to quantify cue integration across thousands of neurons in three navigation-relevant areas: primary visual cortex (V1), retrosplenial cortex (RSC), and medial entorhinal cortex (MEC). Compared with V1 and RSC, path integration influences position estimates more in MEC, and conflicts between path integration and landmarks trigger remapping more readily. Whereas MEC codes position prospectively, V1 codes position retrospectively, and RSC is intermediate between the two. Lowered visual contrast increases the influence of path integration on position estimates only in MEC. These properties are most pronounced in a population of MEC neurons, overlapping with grid cells, tuned to distance run in darkness. These results demonstrate the specialized role that path integration plays in MEC compared with other navigation-relevant cortical areas. Campbell et al. use Neuropixels recordings in mice navigating a VR environment to show that MEC neurons are more influenced by path integration than V1 and RSC neurons. These differences are driven by a subset of MEC neurons that exhibit modular distance tuning in darkness, reminiscent of grid cells.
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