Natural products for the treatment of trachoma and Chlamydia trachomatis.
Natural products for the treatment of trachoma and Chlamydia trachomatis.
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DOI：
10.3390/molecules20034180
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发表时间：
2015-03-05
期刊：
影响因子：
--
通讯作者：
Cho NJ
中科院分区：
文献类型：
--
作者：
Potroz MG;Cho NJ
被忽视的热带疾病(NTD)沙眼是目前世界上导致眼病的主要原因，而导致这种疾病的病原菌沙眼衣原体也是最常见的性传播病原菌。虽然这种细菌的血清型在眼部感染和生殖器感染之间通常有所不同，但生殖器沙眼衣原体感染与婴儿沙眼的发生之间存在明显的联系，因此这些感染的解决方案密切相关。沙眼衣原体独特的生命周期主要导致慢性感染和使用常规抗生素治疗的挑战。这个生命周期包括感染性基本体(EBS)和生殖网状小体(RBS)两个阶段。大多数抗生素只针对生殖性RBS，这往往导致需要延长治疗时间，从而促进耐药病原体的发展。正是通过将几种化合物结合起来获得多种抗菌机制，我们最有可能开发出一种可靠的方法来解决所有这些问题。传统和民族植物学医学为基于协同和多种复合疗法的新配方和治疗方案的开发提供了宝贵的资源。在这篇综述中，我们打算总结现有的文献，关于天然化合物在控制沙眼和抑制衣原体细菌方面的应用，并探索开发新的治疗方式的潜力。
The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities.
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影响因子：
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作者：
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影响因子：
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